HUS1

Gene Symbol HUS1
Entrez Gene 3364
Alt Symbol hHUS1
Species Human
Gene Type protein-coding
Description HUS1 checkpoint homolog (S. pombe)
Other Description checkpoint protein HUS1|hus1+-like protein
Swissprots B4DFI9 O60921
Accessions AAM18968 EAL23807 EAW61001 EAW61002 O60921 AF076844 AAC95526 AF110393 AAD25350 AJ227901 AK290459 BAF83148 AK294117 BAG57450 BC007013 AAH07013 BG286955 BT019481 AAV38288 BT019482 AAV38289 CA438762 CR536552 CAG38789 Y16893 CAA76518 NM_004507 NP_004498 NR_037917
Function Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000269|PubMed:21659603}.
Subcellular Location Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:10777662}.

Checkpoint protein HUS1 (HUS1), Human, ELISA Kit - E01C2307 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

HUS1 (Human) IP-WB Antibody Pair - H00003364-PW2 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

HUS1 (Human) IP-WB Antibody Pair - H00003364-PW3 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

HUS1 (Human) Matched Antibody Pair - H00003364-AP11 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7245871 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7208006 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7215456 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7219044 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7232102 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7209320 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7233143 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7247007 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7252127 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7212989 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7245514 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Checkpoint protein HUS1 (HUS1), ELISA Kit - MBS7211222 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human HUS1 ELISA Kit - E007937 from Biobool

Category ELISA Kit
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