HUS1

Gene Symbol	HUS1
Entrez Gene	3364
Alt Symbol	hHUS1
Species	Human
Gene Type	protein-coding
Description	HUS1 checkpoint homolog (S. pombe)
Other Description	checkpoint protein HUS1|hus1+-like protein
Swissprots	B4DFI9 O60921
Accessions	AAM18968 EAL23807 EAW61001 EAW61002 O60921 AF076844 AAC95526 AF110393 AAD25350 AJ227901 AK290459 BAF83148 AK294117 BAG57450 BC007013 AAH07013 BG286955 BT019481 AAV38288 BT019482 AAV38289 CA438762 CR536552 CAG38789 Y16893 CAA76518 NM_004507 NP_004498 NR_037917
Function	Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000269|PubMed:21659603}.
Subcellular Location	Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10777662}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HUS1 full length protein - ab152054 from Abcam Category Protein Source E. coli Species Human

Human HUS1 full length protein - ab101944 from Abcam Category Protein Source E. coli Species Human

Human HUS1 peptide - ab23254 from Abcam Category Peptide Species Human

HUS1 Antibody Blocking Peptide - LS-E4574 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HUS1 Recombinant Protein - H00003364-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HUS1 Protein - NBP1-50899 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

HUS1-Antibody-C-term-Blocking-Peptide - BP16922b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HUS1 Protein (OPPA02582) - OPPA02582 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

Human HUS1 protein - orb168536 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Species Human

Human HUS1 protein - orb244281 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

HUS1 protein (His tag) - 80R-1576 from Fitzgerald Category Protein Prices $255.00 Sizes 10 µg Source E.coli

HUS1 (1-280, His-tag) - AR09755PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

HUS1 (1-280, His-tag) - AR09755PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

HUS1 - H00003364-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HUS1 - H00003364-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Checkpoint protein HUS1, HUS1, Human, Recombinant - 19-CE53 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

HUS1, 1-280aa, Human, His tag, E.coli - 01-P0815 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

HUS1 fusion protein - ag1744 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

HUS1 Human - PRPS-046 from NeoScientific Category Protein Prices $65.00, $169.00, $1,430.00 Sizes 1 µg, 5 µg, 50 µg Source Escherichia Coli. Species Human

Recombinant Human HUS1 Protein - BP001647-CE53 from Syd Labs Category Protein Prices $180.00, $528.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human HUS1 Protein - BP001647-PRO-039 from Syd Labs Category Protein Prices $160.00, $1,100.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

HUS1, 1-280aa, Recombinant Protein - GWB-P1223A from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 10 μg, 50 μg Source E.coli Species Human

HUS1 Human Protein - GWB-BSP509 from Genway Biotech Category Protein Prices $75.00, $165.00, $1,435.00 Sizes 1 μg, 5 μg, 50 μg Source Escherichia Coli. Species Human

Recombinant Human HUS1, His-tagged - HUS1-3364H from Creative Biomart Category Protein Source E.coli.

Recombinant Human HUS1, His-tagged - HUS1-29414TH from Creative Biomart Category Protein Source E. coli

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