| Gene Symbol |
HUS1
|
| Entrez Gene |
3364
|
| Alt Symbol |
hHUS1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HUS1 checkpoint homolog (S. pombe)
|
| Other Description |
checkpoint protein HUS1|hus1+-like protein
|
| Swissprots |
B4DFI9 O60921
|
| Accessions |
AAM18968 EAL23807 EAW61001 EAW61002 O60921 AF076844 AAC95526 AF110393 AAD25350 AJ227901 AK290459 BAF83148 AK294117 BAG57450 BC007013 AAH07013 BG286955 BT019481 AAV38288 BT019482 AAV38289 CA438762 CR536552 CAG38789 Y16893 CAA76518 NM_004507 NP_004498 NR_037917
|
| Function |
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000269|PubMed:21659603}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10777662}.
|
![Western Blot: HUS1 Overexpression Lysate (Adult Normal) [NBL1-11788] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HUS1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6776_HUS1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11788-img0002.jpg)