| Gene Symbol | HUS1 |
|---|---|
| Entrez Gene | 3364 |
| Alt Symbol | hHUS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | HUS1 checkpoint homolog (S. pombe) |
| Other Description | checkpoint protein HUS1|hus1+-like protein |
| Swissprots | B4DFI9 O60921 |
| Accessions | AAM18968 EAL23807 EAW61001 EAW61002 O60921 AF076844 AAC95526 AF110393 AAD25350 AJ227901 AK290459 BAF83148 AK294117 BAG57450 BC007013 AAH07013 BG286955 BT019481 AAV38288 BT019482 AAV38289 CA438762 CR536552 CAG38789 Y16893 CAA76518 NM_004507 NP_004498 NR_037917 |
| Function | Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. {ECO:0000269|PubMed:21659603}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between the nucleus and the cytoplasm. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10777662}. |