CASQ2

Gene Symbol CASQ2
Entrez Gene 845
Alt Symbol PDIB2
Species Human
Gene Type protein-coding
Description calsequestrin 2 (cardiac muscle)
Other Description calsequestrin 2, fast-twitch, cardiac muscle|calsequestrin, cardiac muscle isoform|calsequestrin-2
Swissprots Q8TBW8 Q5T1D2 O14958 B4DIB0 B2R7M6
Accessions CCQ43132 EAW56635 EAW56636 O14958 AK129831 AK129891 AK225959 AK293595 BAG57061 AK295502 BAG58422 AK313041 BAG35873 BC022288 AAH22288 BM679349 D55655 BAA23494 DC423064 DQ893219 ABM84145 DQ896548 ABM87547 NM_001232 NP_001223
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.
Subcellular Location Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.

calsequestrin 2 (E-12) - sc-390999 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
calsequestrin 2 (E-12): sc-390999. Western blot analysis of calsequestrin 2 expression in non-transfected: sc-117752 (A) and human calsequestrin 2 transfected: sc-172435 (B) 293T whole cell lysates and mouse heart (C), rat heart (D) and human heart (E) tissue extracts.

calsequestrin 2 (C-16) - sc-16576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
calsequestrin 2 (C-16): sc-16576. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

calsequestrin 2 (H-60) - sc-28275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
calsequestrin 2 (H-60): sc-28275. Western blot analysis of human recombinant calsequestrin 2 fusion protein.

calsequestrin 2 (N-18) - sc-16574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
calsequestrin 2 (N-18): sc-16574. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

Anti-Calsequestrin 2 antibody - ab96387 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Calsequestrin 2 antibody (ab96387) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-Calsequestrin 2 antibody - ab54858 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54858 Calsequestrin 2 antibody at 1ug/ml.

Anti-Calsequestrin 2 antibody [1C6] - ab124270 from Abcam

Prices $464.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C6
ab124270, at 3 µg/ml, staining Calsequestrin in formalin fixed, paraffin embedded Human skeletal muscle tissue by Immunohistochemistry.

Anti-Calsequestrin 2 antibody [EPR4227] - ab108289 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4227
All lanes : Anti-Calsequestrin 2 antibody [EPR4227] (ab108289) at 1/1000 dilutionLane 1 : Human heart cell lysateLane 2 : Mouse heart lysateLane 3 : Rat heart lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Calsequestrin 2 antibody [EPR4228] - ab108381 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4228
All lanes : Anti-Calsequestrin 2 antibody [EPR4228] (ab108381) at 1/1000 dilutionLane 1 : Human heart lysateLane 2 : Human skeletal muscle lysateLysates/proteins at 10 µg per lane.

Anti-CASQ2 / Calsequestrin 2 Antibody (clone 1C6) IHC-plus™ - LS-B6015 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C6
Anti-CASQ2 / Calsequestrin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6015 concentration 5 ug/ml.

Anti-CASQ2 / Calsequestrin 2 Antibody (aa20-399, clone GF1) - LS-C190164 from LifeSpan Bioscience

Prices $375.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone GF1

Anti-CASQ2 / Calsequestrin 2 Antibody (aa32-81) - LS-C151561 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CASQ2 / Calsequestrin 2 antibody Western Blot of Fetal Heart.

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, APC) - LS-C253439 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (clone AT4E10) - LS-C139555 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT4E10

Anti-CASQ2 / Calsequestrin 2 Antibody (Internal, clone EPR4227) - LS-C137841 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4227
Fig 1. Western blot analysis on (A) human heart, (B) mouse heart, and (C) rat heart lysates using anti-Calsequestrin-2 antibody.

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, AP) - LS-C253438 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, Biotin) - LS-C253440 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, FITC) - LS-C253443 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107) - LS-C157601 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CASQ2 Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The CASQ2 antibody detected the CASQ2 protein (arrow).

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, Azide-free, HRP) - LS-C253444 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107, PE) - LS-C253445 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa124-388) - LS-C185748 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Cal27 xenograft using Calsequestrin-2 antibody at 1:500 dilution.

Anti-CASQ2 / Calsequestrin 2 Antibody - LS-C309723 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (aa79-107) - LS-C329315 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CASQ2 / Calsequestrin 2 Antibody (Internal, clone EPR4228) - LS-C137803 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4228
IHC of paraffin-embedded human skeletal muscles using anti-Calsequestrin-2 antibody.
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