CASQ2

Gene Symbol CASQ2
Entrez Gene 845
Alt Symbol PDIB2
Species Human
Gene Type protein-coding
Description calsequestrin 2 (cardiac muscle)
Other Description calsequestrin 2, fast-twitch, cardiac muscle|calsequestrin, cardiac muscle isoform|calsequestrin-2
Swissprots Q8TBW8 Q5T1D2 O14958 B4DIB0 B2R7M6
Accessions CCQ43132 EAW56635 EAW56636 O14958 AK129831 AK129891 AK225959 AK293595 BAG57061 AK295502 BAG58422 AK313041 BAG35873 BC022288 AAH22288 BM679349 D55655 BAA23494 DC423064 DQ893219 ABM84145 DQ896548 ABM87547 NM_001232 NP_001223
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.
Subcellular Location Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.

calsequestrin 2 CRISPR/Cas9 KO Plasmid (h) - sc-402912 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 HDR Plasmid (h) - sc-402912-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 Double Nickase Plasmid (h) - sc-402912-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 Double Nickase Plasmid (h2) - sc-402912-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 CRISPR Activation Plasmid (h) - sc-402912-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 CRISPR Activation Plasmid (h2) - sc-402912-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 Lentiviral Activation Particles (h) - sc-402912-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 Lentiviral Activation Particles (h2) - sc-402912-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

calsequestrin 2 siRNA (h) - sc-43277 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

calsequestrin 2 shRNA Plasmid (h) - sc-43277-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

calsequestrin 2 shRNA (h) Lentiviral Particles - sc-43277-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU023681 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5391 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5391 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08480 from Sigma-Aldrich

Category miRNA

CASQ2 siRNA (Human) - CRH0599 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Calsequestrin 2 RNAi - H00000845-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

CASQ2 - MBS8232159 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CASQ2 (NM_001232.3) - SHH255073 from Creative biogene

Category siRNA
Species Reactivities Human

Human CASQ2 siRNA - orb261101 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASQ2 shRNA Plasmid (Human) - CHH0599 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CASQ2 miRNA 3'UTR clone - MiUTR3H-00338 from Creative biogene

Species Reactivities Human
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