| Gene Symbol |
CASQ2
|
| Entrez Gene |
845
|
| Alt Symbol |
PDIB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calsequestrin 2 (cardiac muscle)
|
| Other Description |
calsequestrin 2, fast-twitch, cardiac muscle|calsequestrin, cardiac muscle isoform|calsequestrin-2
|
| Swissprots |
Q8TBW8 Q5T1D2 O14958 B4DIB0 B2R7M6
|
| Accessions |
CCQ43132 EAW56635 EAW56636 O14958 AK129831 AK129891 AK225959 AK293595 BAG57061 AK295502 BAG58422 AK313041 BAG35873 BC022288 AAH22288 BM679349 D55655 BAA23494 DC423064 DQ893219 ABM84145 DQ896548 ABM87547 NM_001232 NP_001223
|
| Function |
Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.
|
| Subcellular Location |
Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.
|
![Western Blot: Calsequestrin 2 Overexpression Lysate (Adult Normal) [NBL1-08720] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Calsequestrin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4551_Calsequestrin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08720-img0002.jpg)