CASQ2

Gene Symbol	CASQ2
Entrez Gene	845
Alt Symbol	PDIB2
Species	Human
Gene Type	protein-coding
Description	calsequestrin 2 (cardiac muscle)
Other Description	calsequestrin 2, fast-twitch, cardiac muscle|calsequestrin, cardiac muscle isoform|calsequestrin-2
Swissprots	Q8TBW8 Q5T1D2 O14958 B4DIB0 B2R7M6
Accessions	CCQ43132 EAW56635 EAW56636 O14958 AK129831 AK129891 AK225959 AK293595 BAG57061 AK295502 BAG58422 AK313041 BAG35873 BC022288 AAH22288 BM679349 D55655 BAA23494 DC423064 DQ893219 ABM84145 DQ896548 ABM87547 NM_001232 NP_001223
Function	Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16908766, ECO:0000269|PubMed:17881003, ECO:0000269|PubMed:18399795, ECO:0000269|PubMed:21416293}.
Subcellular Location	Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Calsequestrin 2 full length protein - ab158035 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Calsequestrin 2 full length protein - ab93736 from Abcam Category Protein Prices $188.00, $692.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human Calsequestrin 2 protein fragment - ab158036 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CASQ2 / Calsequestrin 2 Antibody Blocking Peptide - LS-E23285 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Calsequestrin 2 Recombinant Protein - H00000845-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Calsequestrin 2 Partial Recombinant Protein - H00000845-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Calsequestrin 2 Protein - NBP1-41229 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

CASQ2 Protein (OPPA02269) - OPPA02269 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Calsequestrin protein - orb80991 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Source E.coli

CASQ2 Dog protein - orb80992 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Dog

Calsequestrin2 protein (His tag) - 80R-1273 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

Calsequestrin-2 (20-399, His-tag) - AR09401PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

Calsequestrin-2 (20-399, His-tag) - AR09401PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

Calsequestrin-2 - H00000845-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Calsequestrin-2 - H00000845-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Calsequestrin-2 - H00000845-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Calsequestrin-2 - H00000845-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Calsequestrin-2, Human Recombinant - 228-13241-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Calsequestrin-2 - 228-13241-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Calsequestrin-2 - 228-13241-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

Calsequestrin-2, 20-399aa, Human, His tag, E.coli - 01-1799-2 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CASQ2 fusion protein - Ag13246 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

CASQ2 Human - PRPS-806 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Dog Calsequestrin-2 Protein - BP000483-PRO-410 from Syd Labs Category Protein Prices $175.00, $270.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source Dog Heart-derived. Species Dog

Recombinant Human Calsequestrin-2 Protein - BP000483-PRO-799 from Syd Labs Category Protein Prices $160.00, $210.00, $2,250.00 Sizes 25 µg, 500 µg, 1 mg Source E. coli-derived. Species Human

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