UGT1A1

Gene Symbol	UGT1A1
Entrez Gene	54658
Alt Symbol	BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species	Human
Gene Type	protein-coding
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Other Description	UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Swissprots	P22309 B8K286 A6NJC3
Accessions	AAA61248 AAF01205 AAG30424 AAG43197 AAK27223 AAK31204 AAS99732 ABC88474 ACI45243 BAA25600 BAO48177 BAO48178 BAO48179 BAO48180 BAO48181 EAW71053 P22309 AK290834 BAF83523 AY435136 AAR95637 BC128414 AAI28415 BC128415 AAI28416 DQ364247 ABC96771 JQ686667 AFH35129 JQ699637 AFN10613 JQ699638 AFN10614 JQ699639 AFN10615 JQ699640 AFN10616 JQ699641 AFN10617 JQ699642 AFN10618 JQ699643 AFN10619 JQ699644 AFN10620 JQ699645 AFN10621 JQ699646 AFN10622 JQ699647 AFN10623 JQ699649 AFN10624 JQ699650 AFN10625 M57899 AAA63195 NM_000463 NP_000454
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808}.
Subcellular Location	Isoform 1: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UGT Antibody - 4371 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

UGT1A (H-300) - sc-25847 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

UGT1A (C-19) - sc-27418 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UGT1A1 (D-16) - sc-27415 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

UGT1A1 (N-20) - sc-27413 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-UGT1A1 antibody - ab62600 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A1 antibody - ab194697 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A1 antibody - ab116319 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A1 antibody - ab84021 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A1 antibody [EPR9592] - ab170858 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9592

Anti-UGT1A / UGT1A1 Antibody (aa60-168) - LS-C184920 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, AP) - LS-C218259 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, FITC) - LS-C218262 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, APC) - LS-C218260 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, Biotin) - LS-C218261 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, Azide-free, HRP) - LS-C218265 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90, PE) - LS-C218266 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa64-91) - LS-C326170 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody - LS-C341955 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa251-300) - LS-C40468 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa36-85) - LS-C102087 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody - LS-C334543 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-UGT1A / UGT1A1 Antibody (aa65-90) - LS-C160417 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Glucuronosyltransferase 1A1/UGT1A1 Antibody - AF6490 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Glucuronosyltransferase 1A1/UGT1A1 Antibody (856754) [Unconjugated] - MAB6490 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 856754

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