UGT1A1

Gene Symbol	UGT1A1
Entrez Gene	54658
Alt Symbol	BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species	Human
Gene Type	protein-coding
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Other Description	UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Swissprots	P22309 B8K286 A6NJC3
Accessions	AAA61248 AAF01205 AAG30424 AAG43197 AAK27223 AAK31204 AAS99732 ABC88474 ACI45243 BAA25600 BAO48177 BAO48178 BAO48179 BAO48180 BAO48181 EAW71053 P22309 AK290834 BAF83523 AY435136 AAR95637 BC128414 AAI28415 BC128415 AAI28416 DQ364247 ABC96771 JQ686667 AFH35129 JQ699637 AFN10613 JQ699638 AFN10614 JQ699639 AFN10615 JQ699640 AFN10616 JQ699641 AFN10617 JQ699642 AFN10618 JQ699643 AFN10619 JQ699644 AFN10620 JQ699645 AFN10621 JQ699646 AFN10622 JQ699647 AFN10623 JQ699649 AFN10624 JQ699650 AFN10625 M57899 AAA63195 NM_000463 NP_000454
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808}.
Subcellular Location	Isoform 1: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat UGT1A / UGT1A1 ELISA Kit (Sandwich ELISA) - LS-F8467 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Human UGT1A / UGT1A1 ELISA Kit (Sandwich ELISA) - LS-F8610 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.63 ng/ml Range 1.56-100 ng/ml

Human UGT1A / UGT1A1 ELISA Kit (Sandwich ELISA) - LS-F12906 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 1.56-100 ng/ml

UDP-glucuronosyltransferase 1-1, UGT1A1, Human, ELISA Kit - E12952h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

UDP glucuronosyltransferase 1 family, polypeptide A1, ELISA Kit - MBS700185 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS097849 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS084540 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS089187 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS096939 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS049344 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS098005 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1, ELISA Kit - MBS076022 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1), ELISA Kit - MBS2020273 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.55ng/mL. Range 1.56-100ng/mL

UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1), ELISA Kit - MBS2023366 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.58ng/mL. Range 1.56-100ng/mL

ELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) - SEG920Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.58ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) - SEG920Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.55ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

Human UDP-glucumno-syltransferase 1(UGT1) ELISA Kit - CSB-E14183h from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Rat UGT1A / UGT1A1 ELISA Kit (Custom ELISA) - LS-F16784 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 1.56-100 ng/ml

Mouse UGT1A / UGT1A1 ELISA Kit (Custom ELISA) - LS-F16783 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 1.56-100 ng/ml

Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) ELISA Kit - EKU08029 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.59 ng/mL Range 1.56-100 ng/mL

Human UDP-glucuronosyltransferase 1-1 ELISA Kit - abx250749 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human UGT1A1 ELISA Kit - abx153433 from Abbexa Category ELISA Kit Range 1.56 ng/ml - 100 ng/ml

UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1), Human, ELISA Kit - DL-UGT1A1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 1.56-100 ng/mL

Human UGT1A1 ELISA Kit - orb370095 from Biorbyt Category ELISA Kit Prices $553.00, $621.00 Sizes 48 test, 96 test Range Detection Range: 1.563-100ng/mL Detection low threshold: 0.51ng/mL

Human UDP-glucuronosyltransferase 1-1 ELISA Kit - EKE53855 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.045 ng/ml Range 0.156-10 ng/mL

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