UGT1A1

Gene Symbol	UGT1A1
Entrez Gene	54658
Alt Symbol	BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species	Human
Gene Type	protein-coding
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Other Description	UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Swissprots	P22309 B8K286 A6NJC3
Accessions	AAA61248 AAF01205 AAG30424 AAG43197 AAK27223 AAK31204 AAS99732 ABC88474 ACI45243 BAA25600 BAO48177 BAO48178 BAO48179 BAO48180 BAO48181 EAW71053 P22309 AK290834 BAF83523 AY435136 AAR95637 BC128414 AAI28415 BC128415 AAI28416 DQ364247 ABC96771 JQ686667 AFH35129 JQ699637 AFN10613 JQ699638 AFN10614 JQ699639 AFN10615 JQ699640 AFN10616 JQ699641 AFN10617 JQ699642 AFN10618 JQ699643 AFN10619 JQ699644 AFN10620 JQ699645 AFN10621 JQ699646 AFN10622 JQ699647 AFN10623 JQ699649 AFN10624 JQ699650 AFN10625 M57899 AAA63195 NM_000463 NP_000454
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808}.
Subcellular Location	Isoform 1: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UGT1A1 protein fragment - ab162807 from Abcam Category Protein Source Wheat germ Species Human

Human UGT1A1 protein fragment - ab202607 from Abcam Category Protein Source E. coli Species Human

Glucuronosyltransferase 1A1/UGT1A1 Partial Recombinant Protein - H00054658-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Glucuronosyltransferase 1A1/UGT1A1 Recombinant Protein - P3466 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

UGT1A1-Antibody-N-term-Blocking-peptide - BP13949a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human UGT1A1 protein - orb246799 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

UGT1A1 Blocking Peptide - 33R-1543 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UGT1A1 Blocking Peptide - 33R-1966 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

uGT1A1 protein (His tag) - 80R-4148 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

UGT1A1 (26-490, His-tag) - AR51834PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UGT1A1 (26-490, His-tag) - AR51834PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UGT1A1 - H00054658-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UGT1A1 - H00054658-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UGT1A1 - P3466 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

SOD1, 1-154aa, Human, Recombinant, E.coli - 01-2020 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

UGT1A1 fusion protein - Ag19001 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

UGT1A1 fusion protein - ag18957 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 - UGT1A1-1118H from Creative Biomart Category Protein

Recombinant Human UGT1A1, MYC/DDK-tagged - UGT1A1-26H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) - RPG920Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant UDP Glucuronosyltransferase 1 Family, Polypeptide A1 (UGT1A1) - RPG920Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

SOD1 - PAT-80212-2 from Nordic BioSite Category Protein Species Human

SOD1 - PAT-80212-1 from Nordic BioSite Category Protein Species Human

Recombinant Human UDP-glucuronosyltransferase 1-1(UGT1A1) ,partial - CSB-EP025570HU CSB-BP025570HU CSB-MP025570HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human UDP-glucuronosyltransferase 1-1(UGT1A1) ,partial - CSB-YP025570HU from Cusabio Category Protein Source Yeast Species Human

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