UGT1A1

Gene Symbol UGT1A1
Entrez Gene 54658
Alt Symbol BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species Human
Gene Type protein-coding
Description UDP glucuronosyltransferase 1 family, polypeptide A1
Other Description UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Swissprots P22309 B8K286 A6NJC3
Accessions AAA61248 AAF01205 AAG30424 AAG43197 AAK27223 AAK31204 AAS99732 ABC88474 ACI45243 BAA25600 BAO48177 BAO48178 BAO48179 BAO48180 BAO48181 EAW71053 P22309 AK290834 BAF83523 AY435136 AAR95637 BC128414 AAI28415 BC128415 AAI28416 DQ364247 ABC96771 JQ686667 AFH35129 JQ699637 AFN10613 JQ699638 AFN10614 JQ699639 AFN10615 JQ699640 AFN10616 JQ699641 AFN10617 JQ699642 AFN10618 JQ699643 AFN10619 JQ699644 AFN10620 JQ699645 AFN10621 JQ699646 AFN10622 JQ699647 AFN10623 JQ699649 AFN10624 JQ699650 AFN10625 M57899 AAA63195 NM_000463 NP_000454
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808}.
Subcellular Location Isoform 1: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.
Top Pathways Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

UGT1A1 CRISPR/Cas9 KO Plasmid (h) - sc-401190 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 HDR Plasmid (h) - sc-401190-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 Double Nickase Plasmid (h) - sc-401190-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 Double Nickase Plasmid (h2) - sc-401190-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 CRISPR Activation Plasmid (h) - sc-401190-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 CRISPR Activation Plasmid (h2) - sc-401190-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 Lentiviral Activation Particles (h) - sc-401190-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 Lentiviral Activation Particles (h2) - sc-401190-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A1 siRNA (h) - sc-44181 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UGT1A1 shRNA Plasmid (h) - sc-44181-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UGT1A1 shRNA (h) Lentiviral Particles - sc-44181-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU225871 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22456 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22456 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UGT1A1 siRNA (Human) - CRJ0165 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UGT1A1 - MBS827885 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UGT1A1 (NM_000463.2) - SHH440048 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UGT1A1(NM_000463.2) - SHL105642 from Creative biogene

Category siRNA
Species Reactivities Human

Human UGT1A1 siRNA - orb270666 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UGT1A1 shRNA Plasmid (Human) - CHJ0165 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UGT1A1 miRNA 3'UTR clone - MiUTR1H-10988 from Creative biogene

Species Reactivities Human
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