UGT1A1

Gene Symbol	UGT1A1
Entrez Gene	54658
Alt Symbol	BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
Species	Human
Gene Type	protein-coding
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Other Description	UDP glycosyltransferase 1 family, polypeptide A1|UDP-glucuronosyltransferase 1-1|UDP-glucuronosyltransferase 1-A|UDP-glucuronosyltransferase 1A1|UGT-1A|UGT1*1|UGT1-01|UGT1.1|bilirubin UDP-glucuronosyltransferase 1-1|bilirubin UDP-glucuronosyltransferase isozyme 1|bilirubin-specific UDPGT isozyme 1
Swissprots	P22309 B8K286 A6NJC3
Accessions	AAA61248 AAF01205 AAG30424 AAG43197 AAK27223 AAK31204 AAS99732 ABC88474 ACI45243 BAA25600 BAO48177 BAO48178 BAO48179 BAO48180 BAO48181 EAW71053 P22309 AK290834 BAF83523 AY435136 AAR95637 BC128414 AAI28415 BC128415 AAI28416 DQ364247 ABC96771 JQ686667 AFH35129 JQ699637 AFN10613 JQ699638 AFN10614 JQ699639 AFN10615 JQ699640 AFN10616 JQ699641 AFN10617 JQ699642 AFN10618 JQ699643 AFN10619 JQ699644 AFN10620 JQ699645 AFN10621 JQ699646 AFN10622 JQ699647 AFN10623 JQ699649 AFN10624 JQ699650 AFN10625 M57899 AAA63195 NM_000463 NP_000454
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. {ECO:0000269|PubMed:18004206, ECO:0000269|PubMed:19545173, ECO:0000269|PubMed:19830808}.
Subcellular Location	Isoform 1: Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in liver, colon and small intestine. Isoform 2 but not isoform 1 is expressed in kidney. Isoform 1 and isoform 2 are not expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:17187418, ECO:0000269|PubMed:18004212}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Pentose and glucuronate interconversions, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UGT1A1 - MBS1267459 from MyBioSource Species Human Accession BC128415

Human UGT1A1 cDNA clone(NM_000463.2) - CDFH020824 from Creative Biomart Species Human Accession NM_000463.2

Human UGT1A1 ORF Clone(NM_000463.2) - CDCR336545 from Creative Biomart Species Human Accession NM_000463.2

Human UGT1A1 ORF Clone(NM_000463.2) - CDCR336546 from Creative Biomart Species Human Accession NM_000463.2

Human UGT1A1 ORF Clone(NM_000463.2) - CDCR336548 from Creative Biomart Species Human Accession NM_000463.2

Human UGT1A1 ORF clone(NM_000463.2) - CDCL186677 from Creative Biomart Species Human Accession NM_000463.2

human UGT1A1 ORF clone - CDCH097964 from Creative Biomart Species Human Accession NM_000463

human UGT1A1 ORF clone - CDCH097965 from Creative Biomart Species Human Accession NM_000463

Human UGT1A1 ORF Clone(NM_000463.2) - CDCL180475 from Creative Biomart Species Human Accession NM_000463.2

Human UGT1A1 Gene ORF cDNA clone in cloning vector - HG13313-G from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13313-CY from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13313-NF from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13313-NM from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13313-CF from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, N-His tag - HG13313-NH from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13313-CM from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13313-NY from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13313-ACR from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-His tag - HG13313-CH from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13313-ACG from Sino Biological Species Human

Human UGT1A1 Gene ORF cDNA clone expression plasmid - HG13313-UT from Sino Biological Species Human

Human UGT1A1 ORF clone(NM_000463.2) - CDCL186677 from Creative biogene Species Human

Human UGT1A1 ORF Clone (BC128415) - CDCS405676 from Creative biogene Species Human Accession P22309

Human UGT1A1 cDNA Clone(NM_000463.2) - CDFH020824 from Creative biogene Species Human

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