LAMP2
| Gene Symbol | LAMP2 |
|---|---|
| Entrez Gene | 3920 |
| Alt Symbol | CD107b, LAMP-2, LAMPB, LGP110 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lysosomal-associated membrane protein 2 |
| Other Description | CD107 antigen-like family member B|lysosome-associated membrane glycoprotein 2 |
| Swissprots | Q99534 Q96J30 Q6Q3G8 A8K4X5 Q16641 P13473 D3DTF0 Q9UD93 |
| Accessions | AAB41647 AAB67313 AAB67314 EAX11881 EAX11882 EAX11883 EAX11884 P13473 AK291090 BAF83779 AK293931 BAG57310 AK295038 BAH11955 AK304405 BAG65239 AY561849 AAS67876 BC002965 AAH02965 BC040653 BP386088 DA405328 DQ892095 ABM83021 DQ895288 ABM86214 J04183 AAA60383 S79873 AAB35426 U36336 AAA91149 X77196 CAA54416 NM_001122606 NP_001116078 NM_002294 NP_002285 NM_013995 NP_054701 |
| Function | Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. {ECO:0000269|PubMed:8407947}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255|PROSITE- ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Endosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. |
| Tissue Specificity | Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver. |
| Top Pathways | Lysosome, Phagosome, Tuberculosis |
LAMP-2 CRISPR/Cas9 KO Plasmid (h) - sc-400215 from Santa Cruz Biotechnology
|
||||||||
LAMP-2 HDR Plasmid (h) - sc-400215-HDR from Santa Cruz Biotechnology
|
||||||||
LAMP-2 Double Nickase Plasmid (h) - sc-400215-NIC from Santa Cruz Biotechnology
|
||||||||
LAMP-2 Double Nickase Plasmid (h2) - sc-400215-NIC-2 from Santa Cruz Biotechnology
|
||||||||
LAMP-2 CRISPR Activation Plasmid (h) - sc-400215-ACT from Santa Cruz Biotechnology
|
||||||||
LAMP-2 CRISPR Activation Plasmid (h2) - sc-400215-ACT-2 from Santa Cruz Biotechnology
|
||||||||
LAMP-2 Lentiviral Activation Particles (h) - sc-400215-LAC from Santa Cruz Biotechnology
|
||||||||
LAMP-2 Lentiviral Activation Particles (h2) - sc-400215-LAC-2 from Santa Cruz Biotechnology
|
||||||||
LAMP-2 siRNA (h) - sc-29390 from Santa Cruz Biotechnology
|
||||||||
LAMP-2 shRNA Plasmid (h) - sc-29390-SH from Santa Cruz Biotechnology
|
||||||||
LAMP-2 shRNA (h) Lentiviral Particles - sc-29390-V from Santa Cruz Biotechnology
|
||||||||
LAMP-2/CD107b RNAi - H00003920-R01 from Novus Biologicals
|
||||||||
LAMP-2/CD107b RNAi - H00003920-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU065091 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN11540 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11540 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR12941 from Sigma-Aldrich
|
||||||||
LAMP2 siRNA (Human) - CRH2657 from Cohesion Biosciences
|
||||||||
shRNA set against Human LAMP2 (NM_002294.2) - SHH328347 from Creative biogene
|
||||||||
Human LAMP2 siRNA - orb263159 from Biorbyt
|
||||||||
LAMP2 shRNA Plasmid (Human) - CHH2657 from Cohesion Biosciences
|