| Gene Symbol | SMC5 |
|---|---|
| Entrez Gene | 23137 |
| Alt Symbol | SMC5L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | structural maintenance of chromosomes 5 |
| Other Description | SMC protein 5|SMC-5|SMC5 structural maintenance of chromosomes 5-like 1|hSMC5|structural maintenance of chromosomes protein 5 |
| Swissprots | A6NM81 Q8IY18 Q05D92 Q5VZ60 Q96SB9 O60335 |
| Accessions | EAW62501 EAW62502 Q8IY18 AA709087 AB011166 BAA25520 AJ310550 CAC39247 AK055825 AK304133 BAG65027 BC017666 AAH17666 BC020393 BC034441 BC038225 AAH38225 DB220819 DB318469 DQ893364 ABM84290 DQ896768 ABM87767 XM_005251837 XP_005251894 XM_005251838 XP_005251895 XM_005251839 XP_005251896 NM_015110 NP_055925 |
| Function | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785}. |
| Subcellular Location | Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11408570}. |
Structural maintenance of chromosomes protein 5 (SMC5), Human, ELISA Kit - E01S0383 from ARP American Research Products
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7225858 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7206162 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7233580 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7204434 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7210869 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7231356 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7216257 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7214527 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7239646 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7204835 from MyBioSource
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Structural maintenance of chromosomes protein 5 (SMC5), ELISA Kit - MBS7232488 from MyBioSource
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Human SMC5 ELISA Kit - E036832 from Biobool
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