SMC5

Gene Symbol SMC5
Entrez Gene 23137
Alt Symbol SMC5L1
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 5
Other Description SMC protein 5|SMC-5|SMC5 structural maintenance of chromosomes 5-like 1|hSMC5|structural maintenance of chromosomes protein 5
Swissprots A6NM81 Q8IY18 Q05D92 Q5VZ60 Q96SB9 O60335
Accessions EAW62501 EAW62502 Q8IY18 AA709087 AB011166 BAA25520 AJ310550 CAC39247 AK055825 AK304133 BAG65027 BC017666 AAH17666 BC020393 BC034441 BC038225 AAH38225 DB220819 DB318469 DQ893364 ABM84290 DQ896768 ABM87767 XM_005251837 XP_005251894 XM_005251838 XP_005251895 XM_005251839 XP_005251896 NM_015110 NP_055925
Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785}.
Subcellular Location Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11408570}.

SMC5 CRISPR/Cas9 KO Plasmid (h) - sc-405958 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 HDR Plasmid (h) - sc-405958-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 Double Nickase Plasmid (h) - sc-405958-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 Double Nickase Plasmid (h2) - sc-405958-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 CRISPR Activation Plasmid (h) - sc-405958-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 CRISPR Activation Plasmid (h2) - sc-405958-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 Lentiviral Activation Particles (h) - sc-405958-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 Lentiviral Activation Particles (h2) - sc-405958-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC5 siRNA (h) - sc-61563 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC5 shRNA Plasmid (h) - sc-61563-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC5 shRNA (h) Lentiviral Particles - sc-61563-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC5 RNAi - H00023137-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU100921 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19778 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19778 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11637 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11637

SMC5 siRNA (Human) - CRH8025 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC5 - MBS8211696 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMC5 (NM_015110.3) - SHH413288 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMC5 siRNA - orb268527 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC5 shRNA Plasmid (Human) - CHH8025 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMC5 miRNA 3'UTR clone - MiUTR1H-09656 from Creative biogene

Species Reactivities Human
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