SMC5

Gene Symbol SMC5
Entrez Gene 23137
Alt Symbol SMC5L1
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 5
Other Description SMC protein 5|SMC-5|SMC5 structural maintenance of chromosomes 5-like 1|hSMC5|structural maintenance of chromosomes protein 5
Swissprots A6NM81 Q8IY18 Q05D92 Q5VZ60 Q96SB9 O60335
Accessions EAW62501 EAW62502 Q8IY18 AA709087 AB011166 BAA25520 AJ310550 CAC39247 AK055825 AK304133 BAG65027 BC017666 AAH17666 BC020393 BC034441 BC038225 AAH38225 DB220819 DB318469 DQ893364 ABM84290 DQ896768 ABM87767 XM_005251837 XP_005251894 XM_005251838 XP_005251895 XM_005251839 XP_005251896 NM_015110 NP_055925
Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785}.
Subcellular Location Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11408570}.

SMC5 (B-11) - sc-393282 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMC5 (B-11): sc-393282. Western blot analysis of SMC5 expression in HeLa (A) and Jurkat (B) whole cell lysates and HeLa nuclear extract (C).

SMC5 (C-20) - sc-47627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMC5 (H-190) - sc-134544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SMC5 antibody - ab18038 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC5 antibody - ab185373 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SMC5 antibody (ab185373) at 1/250 dilution + Human RT4 cell lysate

Anti-SMC5 antibody - ab154103 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SMC5 antibody (ab154103) at 1/500 dilution + NT2D1 whole cell lysate at 30 µg

Anti-SMC5 antibody - C-terminal - ab200106 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMC5 antibody - C-terminal (ab200106) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-SMC5 Antibody (C-Terminus) - LS-C91726 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC5 Antibody (aa679-692) - LS-C108899 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMC5 Antibody - LS-C332049 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC5 Antibody (C-Terminus) - LS-C287150 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SMC5 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-SMC5 antibody used for IP at 6 ug/mg lysate. SMC5 was also immunoprecipitated by a prior lot (-1) of this antibody. For blotting immunoprecipitated SMC5, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

SMC5 Antibody - NB100-469 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMC5 Antibody [NB100-469] - Samples: Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, TCMK-1 and NIH3T3 cells. Antibodies: Affinity purified rabbit anti-SMC5 antibody (lot 2) used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

SMC5 Antibody - NBP2-20419 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMC5 Antibody [NBP2-20419] - Sample (30 ug of whole cell lysate) A: NT2D1 5% SDS PAGE diluted at 1:500 The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.

SMC5 Antibody - NBP1-46115 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SMC5 Polyclonal Antibody - bs-7729R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMC5 antibody produced in rabbit - SAB2700100 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SMC5: <B>Cat. No. SAB2700100</B>: Western Blot analysis of SMC5 in extracts from <B>Lanes</B><BR/>A. NT2D1 using <B>Cat. No. SAB2700100</B> at a 1:500 dilution.

SMC5-Antibody-Internal-region - AF2971a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SMC5 Antibody (OAEB00117) - OAEB00117 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

SMC5 antibody - 70R-20400 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

SMC5 Polyclonal Antibody - A2301 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SMC5 antibody.

SMC5 Antibody - abx001871 from Abbexa

Host Rabbit
Clonality Polyclonal

SMC5 antibody - 14178-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Hela cell were subjected to SDS PAGE followed by western blot with 14178-1-AP(SMC5 Antibody) at dilution of 1:1000

SMC5 antibody - H00023137-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-SMC5 Antibody - AC21-1908 from Abcore

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMC5 Antibody (AMCA) - AC21-1908-01 from Abcore

Prices $495.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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