SMC5

Gene Symbol	SMC5
Entrez Gene	23137
Alt Symbol	SMC5L1
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 5
Other Description	SMC protein 5|SMC-5|SMC5 structural maintenance of chromosomes 5-like 1|hSMC5|structural maintenance of chromosomes protein 5
Swissprots	A6NM81 Q8IY18 Q05D92 Q5VZ60 Q96SB9 O60335
Accessions	EAW62501 EAW62502 Q8IY18 AA709087 AB011166 BAA25520 AJ310550 CAC39247 AK055825 AK304133 BAG65027 BC017666 AAH17666 BC020393 BC034441 BC038225 AAH38225 DB220819 DB318469 DQ893364 ABM84290 DQ896768 ABM87767 XM_005251837 XP_005251894 XM_005251838 XP_005251895 XM_005251839 XP_005251896 NM_015110 NP_055925
Function	Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785}.
Subcellular Location	Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:11408570}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMC5 protein fragment - ab161544 from Abcam Category Protein Source Wheat germ Species Human

SMC5 Antibody Blocking Peptide - LS-E27086 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMC5 Protein - H00023137-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMC5 blocking peptide - GTX88264-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

SMC5 Peptide - AC21-1908-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMC5 - H00023137-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMC5 - H00023137-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMC5 Peptide - 42-234P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

SMC5 fusion protein - ag5385 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Structural maintenance of chromosomes protein 5(SMC5) ,partial - CSB-YP810294HU CSB-EP810294HU CSB-BP810294HU CSB-MP810294HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMC5, Peptide - MBS426011 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine, Dog

SMC5 Recombinant Protein Antigen - NBP2-47271PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMC5 Peptide, Human - M34GP14740H from Creative Peptides Category Peptide Source Synthetic. Species Human

Structural maintenance of chromosomes protein 5 (SMC5), partial, Recombinant Protein - MBS1296233 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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