SMC5

Gene Symbol SMC5
Entrez Gene 23137
Alt Symbol SMC5L1
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 5
Other Description SMC protein 5|SMC-5|SMC5 structural maintenance of chromosomes 5-like 1|hSMC5|structural maintenance of chromosomes protein 5
Swissprots A6NM81 Q8IY18 Q05D92 Q5VZ60 Q96SB9 O60335
Accessions EAW62501 EAW62502 Q8IY18 AA709087 AB011166 BAA25520 AJ310550 CAC39247 AK055825 AK304133 BAG65027 BC017666 AAH17666 BC020393 BC034441 BC038225 AAH38225 DB220819 DB318469 DQ893364 ABM84290 DQ896768 ABM87767 XM_005251837 XP_005251894 XM_005251838 XP_005251895 XM_005251839 XP_005251896 NM_015110 NP_055925
Function Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785}.
Subcellular Location Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11408570}.

SMC5 overexpression lysate - LY414796 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SMC5 Overexpression Lysate (Native) - NBP2-07214 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SMC5 Overexpression Lysate (Adult Normal) [NBP2-07214] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMC5.

Panoply™ Human SMC5 Knockdown Stable Cell Line - CSC-DC014740 from Creative biogene

Category Cell Line
Species Human
Search more