Gene Symbol | IL1RL2 |
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Entrez Gene | 8808 |
Alt Symbol | IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2 |
Species | Human |
Gene Type | protein-coding |
Description | interleukin 1 receptor-like 2 |
Other Description | IL-1 receptor-related protein 2|IL-36 receptor|interleukin-1 receptor-like 2|interleukin-1 receptor-related protein 2 |
Swissprots | A4FU63 Q53TU8 Q45H74 Q587I8 Q13525 Q9HB29 |
Accessions | AAX81989 AAY15046 AAZ38712 EAX01798 Q9HB29 AF284434 AAG21368 AK315334 BAG37734 BC107064 AAI07065 U49065 AAB53237 XM_005264035 XP_005264092 XM_005264036 XP_005264093 XM_006712820 XP_006712883 XM_006712822 XP_006712885 XM_011512090 XP_011510392 XM_011512091 XP_011510393 XM_011512092 XP_011510394 XM_011512093 XP_011510395 XM_011512094 XP_011510396 XM_011512095 XP_011510397 XM_011512096 XP_011510398 XM_011512097 XP_011510399 XM_011512098 XP_011510400 XR_923053 NM_003854 NP_003845 |
Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}. |
Subcellular Location | Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}. |
Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:24829417}. |
IL-1Rrp2 (C-22) - sc-130154 from Santa Cruz Biotechnology
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IL-1Rrp2 (Y-14) - sc-168171 from Santa Cruz Biotechnology
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IL-1Rrp2 (D-14) - sc-168167 from Santa Cruz Biotechnology
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Anti-IL1RL2 antibody - ab180894 from Abcam
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Anti-IL1RL2 antibody - ab171844 from Abcam
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Anti-IL1RL2 antibody - ab126999 from Abcam
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Anti-IL1RL2 Antibody (aa256-286, AP) - LS-C215246 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa256-286, APC) - LS-C215247 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa256-286, Azide-free, HRP) - LS-C215250 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa256-286, Biotin) - LS-C215248 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa256-286, FITC) - LS-C215249 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa256-286, PE) - LS-C215251 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, APC) - LS-C219774 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, AP) - LS-C219773 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, Azide-free, HRP) - LS-C219778 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, Biotin) - LS-C219775 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, FITC) - LS-C219776 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus, PE) - LS-C219780 from LifeSpan Bioscience
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Anti-IL1R1 Antibody (C-Terminus) - LS-C327604 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa257-286) - LS-C322213 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa107-156) - LS-C117173 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (aa257-286) IHC-plus⢠- LS-B9085 from LifeSpan Bioscience
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Anti-IL1RL2 Antibody (Internal) IHC-plus⢠- LS-B10135 from LifeSpan Bioscience
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IL-1 Rrp2/IL-1 R6 Antibody [Unconjugated] - AF872 from Novus Biologicals
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IL-1 Rrp2/IL-1 R6 Antibody [Unconjugated] - AF2354 from Novus Biologicals
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