| Gene Symbol |
IL1RL2
|
| Entrez Gene |
8808
|
| Alt Symbol |
IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 1 receptor-like 2
|
| Other Description |
IL-1 receptor-related protein 2|IL-36 receptor|interleukin-1 receptor-like 2|interleukin-1 receptor-related protein 2
|
| Swissprots |
A4FU63 Q53TU8 Q45H74 Q587I8 Q13525 Q9HB29
|
| Accessions |
AAX81989 AAY15046 AAZ38712 EAX01798 Q9HB29 AF284434 AAG21368 AK315334 BAG37734 BC107064 AAI07065 U49065 AAB53237 XM_005264035 XP_005264092 XM_005264036 XP_005264093 XM_006712820 XP_006712883 XM_006712822 XP_006712885 XM_011512090 XP_011510392 XM_011512091 XP_011510393 XM_011512092 XP_011510394 XM_011512093 XP_011510395 XM_011512094 XP_011510396 XM_011512095 XP_011510397 XM_011512096 XP_011510398 XM_011512097 XP_011510399 XM_011512098 XP_011510400 XR_923053 NM_003854 NP_003845
|
| Function |
Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}.
|
| Tissue Specificity |
Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:24829417}.
|