| Gene Symbol | IL1RL2 |
|---|---|
| Entrez Gene | 8808 |
| Alt Symbol | IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor-like 2 |
| Other Description | IL-1 receptor-related protein 2|IL-36 receptor|interleukin-1 receptor-like 2|interleukin-1 receptor-related protein 2 |
| Swissprots | A4FU63 Q53TU8 Q45H74 Q587I8 Q13525 Q9HB29 |
| Accessions | AAX81989 AAY15046 AAZ38712 EAX01798 Q9HB29 AF284434 AAG21368 AK315334 BAG37734 BC107064 AAI07065 U49065 AAB53237 XM_005264035 XP_005264092 XM_005264036 XP_005264093 XM_006712820 XP_006712883 XM_006712822 XP_006712885 XM_011512090 XP_011510392 XM_011512091 XP_011510393 XM_011512092 XP_011510394 XM_011512093 XP_011510395 XM_011512094 XP_011510396 XM_011512095 XP_011510397 XM_011512096 XP_011510398 XM_011512097 XP_011510399 XM_011512098 XP_011510400 XR_923053 NM_003854 NP_003845 |
| Function | Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL- 23/IL-17/IL-22 pathway. {ECO:0000250|UniProtKB:Q9ERS7, ECO:0000269|PubMed:11466363}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:24829417}. |
| Tissue Specificity | Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte- derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:24829417}. |
IL-1Rrp2 CRISPR/Cas9 KO Plasmid (h) - sc-406998 from Santa Cruz Biotechnology
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IL-1Rrp2 HDR Plasmid (h) - sc-406998-HDR from Santa Cruz Biotechnology
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IL-1Rrp2 Double Nickase Plasmid (h) - sc-406998-NIC from Santa Cruz Biotechnology
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IL-1Rrp2 Double Nickase Plasmid (h2) - sc-406998-NIC-2 from Santa Cruz Biotechnology
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IL-1Rrp2 CRISPR Activation Plasmid (h) - sc-406998-ACT from Santa Cruz Biotechnology
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IL-1Rrp2 CRISPR Activation Plasmid (h2) - sc-406998-ACT-2 from Santa Cruz Biotechnology
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IL-1Rrp2 Lentiviral Activation Particles (h) - sc-406998-LAC from Santa Cruz Biotechnology
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IL-1Rrp2 Lentiviral Activation Particles (h2) - sc-406998-LAC-2 from Santa Cruz Biotechnology
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IL-1Rrp2 siRNA (h) - sc-94696 from Santa Cruz Biotechnology
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IL-1Rrp2 shRNA Plasmid (h) - sc-94696-SH from Santa Cruz Biotechnology
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IL-1Rrp2 shRNA (h) Lentiviral Particles - sc-94696-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU136671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10602 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10602 from Sigma-Aldrich
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IL1RL2 siRNA (Human) - CRH5807 from Cohesion Biosciences
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IL1RL2 RNAi - H00008808-R02 from Novus Biologicals
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IL1RL2 - MBS8221688 from MyBioSource
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IL-1Rrp2 CRISPR/Cas9 KO Plasmid (h2) - sc-406998-KO-2 from Santa Cruz Biotechnology
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IL-1Rrp2 HDR Plasmid (h2) - sc-406998-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Il1rl2 (NM_003854.2) - SHH318617 from Creative biogene
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shRNA set against Human IL1RL2(NM_003854.2) - SHR190230 from Creative biogene
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Human IL1RL2 siRNA - orb266309 from Biorbyt
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IL1RL2 shRNA Plasmid (Human) - CHH5807 from Cohesion Biosciences
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IL1RL2 miRNA 3'UTR clone - MiUTR1H-04902 from Creative biogene
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