SIX1

Gene Symbol SIX1
Entrez Gene 6495
Alt Symbol BOS3, DFNA23, TIP39
Species Human
Gene Type protein-coding
Description SIX homeobox 1
Other Description homeobox protein SIX1|sine oculis homeobox homolog 1
Swissprots Q53Y16 Q15475 Q96H64
Accessions AAK06772 CAI61692 EAW80784 EAW80785 Q15475 AK093780 BC008874 AAH08874 BT007083 AAP35746 X91868 CAA62974 NM_005982 NP_005973
Function Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Specifically expressed in skeletal muscle.
Top Pathways Transcriptional misregulation in cancer

SIX1-Over-expression-Lysate - LY14549a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SIX1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 66) or transiently transfected with theSIX1 gene.

SIX1 overexpression lysate - LY401814 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SIX1 293 Cell Lysate - 401618 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SIX1 Overexpression Lysate (Native) - NBL1-15982 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SIX1 Overexpression Lysate (Adult Normal) [NBL1-15982] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIX1.

SIX1 Over-expression Lysate Product - GWB-F09455 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human SIX1 Knockdown Stable Cell Line - CSC-DC014276 from Creative biogene

Category Cell Line
Species Human
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