SIX1

Gene Symbol SIX1
Entrez Gene 6495
Alt Symbol BOS3, DFNA23, TIP39
Species Human
Gene Type protein-coding
Description SIX homeobox 1
Other Description homeobox protein SIX1|sine oculis homeobox homolog 1
Swissprots Q53Y16 Q15475 Q96H64
Accessions AAK06772 CAI61692 EAW80784 EAW80785 Q15475 AK093780 BC008874 AAH08874 BT007083 AAP35746 X91868 CAA62974 NM_005982 NP_005973
Function Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Specifically expressed in skeletal muscle.
Top Pathways Transcriptional misregulation in cancer

SIX1 (D4A8K) Rabbit mAb - 12891 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D4A8K
Western blot analysis of extracts from various cell lines using SIX1 (D4A8K) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Six1 (B-8) - sc-514441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Six1 (B-8): sc-514441. Western blot analysis of Six1 expression in non-transfected: sc-117752 (A) and mouse Six1 transfected: sc-123562 (B) 293T whole cell lysates.

Six1 (A-20) - sc-9709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Six1 (A-20): sc-9709. Western blot analysis of Six1 expression in non-transfected: sc-117752 (A) and mouse Six1 transfected: sc-123562 (B) 293T whole cell lysates.

Six1 (M-120) - sc-9127 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Six1/2/4 (N-19) - sc-9708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Six1/2/4 (N-19): sc-9708. Western blot analysis of Six1/2/4 expression in NIH/3T3 whole cell lysate.

Six1/2/4 (E-11) - sc-398193 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Six1/2/4 (E-11): sc-398193. Western blot analysis of Six1/2/4 expression in SK-OV-3 (A), Hep G2 (B) and NIH/3T3 (C) whole cell lysates, Sol8 nuclear extract (D) and human tonsil tissue extract (E).

Anti-SIX1 antibody - ab84329 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-SIX1 antibody (ab84329) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SIX1 antibody - ab86028 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIX1 antibody (ab86028) at 1/1000 dilutionLane 1 : An un-induced culture of E. coliLane 2 : An induced culture of E. coliLysates/proteins at 1/5000 dilution per lane.SecondaryAnti-Rabbit IgG HRP at 1/1000 dilution

Anti-SIX1 antibody [1H4] - ab119411 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
All lanes : Anti-SIX1 antibody [1H4] (ab119411) (1/2000)Lane 1 : HEK293T cells transfected with control cDNA for 48 hoursLane 2 : HEK293T cells transfected with SIX1 cDNA for 48 hoursLysates/proteins at 5 µg per lane.

Anti-SIX1 Antibody (aa252-266) - LS-C10188 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SIX1 Antibody (aa111-160) - LS-C291338 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIX1 Antibody (aa12-278) - LS-C311566 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SIX1 Antibody (C-Terminus) - LS-C110311 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIX1 antibody LS-C110311 Western blot of PANC1 cell lysate.

Anti-SIX1 Antibody (C-Terminus) - LS-C101389 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIX1 antibody LS-C101389 Western blot of 721_B cell lysate.

Anti-SIX1 Antibody (clone 3C7) - LS-C198200 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C7
Detection limit for recombinant GST tagged SIX1 is approximately 3 ng/ml as a capture antibody.

Anti-SIX1 Antibody (clone 1H4) - LS-C173609 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIX1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIX1.

SIX1 Antibody - NBP1-84264 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SIX1 Antibody [NBP1-84264] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

SIX1 Antibody (1H4) - NBP2-01606 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H4
Western Blot: SIX1 Antibody (1H4) [NBP2-01606] HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SIX1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SIX1.

SIX1 Antibody (3C7) - H00006495-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C7
ELISA: SIX1 Antibody (3C7) [H00006495-M05] - Detection limit for recombinant GST tagged SIX1 is approximately 3ng/ml as a capture antibody.

SIX1 Antibody - H00006495-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-SIX1 antibody produced in rabbit - SAB2104425 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SIX1, antibody produced in rabbit: <B>Cat. No. SAB2104425</B>: Immunoblotting analysis of SIX1 in PANC1 cell lysate with SIX1 anitbody at 1 μg/mL.

Monoclonal Anti-SIX1 antibody produced in mouse - AMAB90544 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CL0185
<B>Immunohistochemistry</B><BR/>Anti-SIX1: <B>Cat. No. AMAB90544</B>: Immunohistochemical staining of human striated muscle shows strong nuclear immunoreactivity in the myocytes.

Anti-SIX1 antibody produced in rabbit - SAB2102157 from Sigma-Aldrich

Prices $347.50
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SIX1: <B>Cat. No.SAB2102157</B>: SIX1 in 721_B cell lysate with SIX1 antibody at 1.0 μg/mL.

Monoclonal Anti-SIX1 antibody produced in mouse - SAB1402356 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C7
<B>ELISA</B><BR/>Monoclonal Anti-SIX1, antibody produced in mouse, clone 3C7, purified immunoglobulin: <B>Cat. No. SAB1402356</B>: Detection limit for recombinant GST tagged SIX1 is approximately 3 ng/mL.

Anti-SIX1 antibody produced in rabbit - HPA001893 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SIX1: <B>Cat. No. HPA001893</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skeletal muscle tissue showing positive nuclear staining of myocytes.
Search more