SIX1

Gene Symbol	SIX1
Entrez Gene	6495
Alt Symbol	BOS3, DFNA23, TIP39
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 1
Other Description	homeobox protein SIX1|sine oculis homeobox homolog 1
Swissprots	Q53Y16 Q15475 Q96H64
Accessions	AAK06772 CAI61692 EAW80784 EAW80785 Q15475 AK093780 BC008874 AAH08874 BT007083 AAP35746 X91868 CAA62974 NM_005982 NP_005973
Function	Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141
Subcellular Location	Nucleus. Cytoplasm.
Tissue Specificity	Specifically expressed in skeletal muscle.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SIX1-cDNA-Clone - DC02523 from Abgent, a WuXi AppTec company Prices $383.40 Sizes 10 µg Species Human Accession BC008874

SIX1 - MBS1266468 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC008874

Human SIX1 ORF Clone(NM_005982.3) - CDCL175530 from Creative Biomart Species Human Accession NM_005982.3

human SIX1 ORF clone - CDCH080474 from Creative Biomart Species Human Accession NM_005982

human SIX1 ORF clone - CDCH080475 from Creative Biomart Species Human Accession NM_005982

Mouse SIX1 ORF clone(NM_009189.3) - CDCH400500 from Creative Biomart

Human SIX1 Gene ORF cDNA clone in cloning vector - HG14616-G from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14616-CY from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14616-ANG from Sino Biological Species Human

Human SIX1 Gene cDNA Clone (full-length ORF Clone), expression ready, His-tagged - HG14616-G-H from Sino Biological Species Human Accession BC008874

Human SIX1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14616-ACR from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14616-ANR from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14616-NF from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-His tag - HG14616-NH from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14616-NY from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14616-CF from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14616-ACG from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14616-CM from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14616-NM from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid, C-His tag - HG14616-CH from Sino Biological Species Human

Human SIX1 Gene ORF cDNA clone expression plasmid - HG14616-UT from Sino Biological Species Human

Human SIX1 ORF Clone (BC008874) - CDCS412512 from Creative biogene Species Human Accession Q15475

Human SIX1 ORF clone (BC008874) - CDCB158970 from Creative biogene Species Human

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