SIX1

Gene Symbol	SIX1
Entrez Gene	6495
Alt Symbol	BOS3, DFNA23, TIP39
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 1
Other Description	homeobox protein SIX1|sine oculis homeobox homolog 1
Swissprots	Q53Y16 Q15475 Q96H64
Accessions	AAK06772 CAI61692 EAW80784 EAW80785 Q15475 AK093780 BC008874 AAH08874 BT007083 AAP35746 X91868 CAA62974 NM_005982 NP_005973
Function	Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141
Subcellular Location	Nucleus. Cytoplasm.
Tissue Specificity	Specifically expressed in skeletal muscle.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIX1 full length protein - ab114768 from Abcam Category Protein Source Wheat germ Species Human

Human SIX1 full length protein - ab134521 from Abcam Category Protein Source E. coli Species Human

Human Tuberoinfundibular peptide peptide - ab42342 from Abcam Category Peptide Species Human

SIX1 Antibody Blocking Peptide - LS-E11331 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX1 Antibody Blocking Peptide - LS-E13939 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX1 Recombinant Protein - H00006495-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SIX1 Protein - NBP2-22809 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Human SIX1 protein - orb169300 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

SIX1 Blocking Peptide - 33R-2703 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIX1 protein (His tag) - 80R-2480 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

SIX1 (1-284, His-tag) - AR50552PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SIX1 (1-284, His-tag) - AR50552PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SIX1 - H00006495-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIX1 - H00006495-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIX1, 1-284aa, Human, His tag, E.coli - 01-P1728 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SIX1 fusion protein - ag1044 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TIP 39 (39 mer) - 101335 from NeoScientific Category Peptide Prices $40.00, $297.00, $495.00 Sizes 1 mg, 5 mg, 10 mg

SIX1, 1-284aa , Human, His tag, E.coli - GWB-P0310K from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human SIX1 - SIX1-30869TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SIX Homeobox 1, His-tagged - SIX1-7160H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Homeobox protein SIX1(SIX1) - CSB-YP618986HU CSB-EP618986HU CSB-BP618986HU CSB-MP618986HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SIX1, 1-284aa, Human, His tag, E.coli (Denatured) - ATGP1728 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SIX1, Peptide - MBS657928 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SIX1, Peptide - MBS658447 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SIX1 Recombinant Protein Antigen - NBP1-84264PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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