SIX1

Gene Symbol SIX1
Entrez Gene 6495
Alt Symbol BOS3, DFNA23, TIP39
Species Human
Gene Type protein-coding
Description SIX homeobox 1
Other Description homeobox protein SIX1|sine oculis homeobox homolog 1
Swissprots Q53Y16 Q15475 Q96H64
Accessions AAK06772 CAI61692 EAW80784 EAW80785 Q15475 AK093780 BC008874 AAH08874 BT007083 AAP35746 X91868 CAA62974 NM_005982 NP_005973
Function Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. {ECO:0000250, ECO:0000269|PubMed:15123840, ECO:0000269|PubMed:15141
Subcellular Location Nucleus. Cytoplasm.
Tissue Specificity Specifically expressed in skeletal muscle.
Top Pathways Transcriptional misregulation in cancer

Six1 CRISPR/Cas9 KO Plasmid (h) - sc-402063 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 HDR Plasmid (h) - sc-402063-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 Double Nickase Plasmid (h) - sc-402063-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 Double Nickase Plasmid (h2) - sc-402063-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 CRISPR Activation Plasmid (h) - sc-402063-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 CRISPR Activation Plasmid (h2) - sc-402063-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 Lentiviral Activation Particles (h) - sc-402063-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 Lentiviral Activation Particles (h2) - sc-402063-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six1 siRNA (h) - sc-38784 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Six1 shRNA Plasmid (h) - sc-38784-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Six1 shRNA (h) Lentiviral Particles - sc-38784-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIX1 RNAi - H00006495-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU137671 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19367 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19367 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SIX1 siRNA (Human) - CRH4391 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIX1 - MBS8227492 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human SIX1 siRNA - orb264893 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIX1 shRNA Plasmid (Human) - CHH4391 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIX1 miRNA 3'UTR clone - MiUTR3H-03946 from Creative biogene

Species Reactivities Human
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