| Gene Symbol |
TIFA
|
| Entrez Gene |
92610
|
| Alt Symbol |
T2BP, T6BP, TIFAA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRAF-interacting protein with forkhead-associated domain
|
| Other Description |
TRAF-interacting protein with FHA domain-containing protein A|TRAF-interacting protein with a forkhead-associated domain|TRAF2 binding protein|TRAF2-binding protein|TRAF6 binding protein|putative MAPK-activating protein PM14|putative NF-kappa-B-activating protein 20
|
| Swissprots |
Q96CG3
|
| Accessions |
AAY40963 EAX06273 Q96CG3 AB062110 BAB86902 AB097011 BAC77364 AB097038 BAC77391 AK292900 BAF85589 BC008294 AAH08294 BC014259 AAH14259 BM680110 BM718895 CA772080 DQ893681 ABM84607 DQ896122 ABM87121 XM_011532413 XP_011530715 NM_052864 NP_443096
|
| Function |
Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226}.
|