Gene Symbol | TIFA |
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Entrez Gene | 92610 |
Alt Symbol | T2BP, T6BP, TIFAA |
Species | Human |
Gene Type | protein-coding |
Description | TRAF-interacting protein with forkhead-associated domain |
Other Description | TRAF-interacting protein with FHA domain-containing protein A|TRAF-interacting protein with a forkhead-associated domain|TRAF2 binding protein|TRAF2-binding protein|TRAF6 binding protein|putative MAPK-activating protein PM14|putative NF-kappa-B-activating protein 20 |
Swissprots | Q96CG3 |
Accessions | AAY40963 EAX06273 Q96CG3 AB062110 BAB86902 AB097011 BAC77364 AB097038 BAC77391 AK292900 BAF85589 BC008294 AAH08294 BC014259 AAH14259 BM680110 BM718895 CA772080 DQ893681 ABM84607 DQ896122 ABM87121 XM_011532413 XP_011530715 NM_052864 NP_443096 |
Function | Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226}. |
T2BP CRISPR/Cas9 KO Plasmid (h) - sc-413948 from Santa Cruz Biotechnology
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T2BP HDR Plasmid (h) - sc-413948-HDR from Santa Cruz Biotechnology
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T2BP Double Nickase Plasmid (h) - sc-413948-NIC from Santa Cruz Biotechnology
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T2BP Double Nickase Plasmid (h2) - sc-413948-NIC-2 from Santa Cruz Biotechnology
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T2BP CRISPR Activation Plasmid (h) - sc-413948-ACT from Santa Cruz Biotechnology
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T2BP CRISPR Activation Plasmid (h2) - sc-413948-ACT-2 from Santa Cruz Biotechnology
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T2BP Lentiviral Activation Particles (h) - sc-413948-LAC from Santa Cruz Biotechnology
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T2BP Lentiviral Activation Particles (h2) - sc-413948-LAC-2 from Santa Cruz Biotechnology
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T2BP siRNA (h) - sc-89114 from Santa Cruz Biotechnology
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T2BP shRNA Plasmid (h) - sc-89114-SH from Santa Cruz Biotechnology
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T2BP shRNA (h) Lentiviral Particles - sc-89114-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21344 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21344 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11115 from Sigma-Aldrich
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TIFA siRNA (Human) - CRJ4153 from Cohesion Biosciences
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TIFA - MBS8241222 from MyBioSource
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shRNA set against Human TIFA (NM_052864.2) - SHH427264 from Creative biogene
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Human TIFA siRNA - orb274654 from Biorbyt
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TIFA shRNA Plasmid (Human) - CHJ4153 from Cohesion Biosciences
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TIFA miRNA 3'UTR clone - MiUTR1H-10407 from Creative biogene
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