Gene Symbol | TIFA |
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Entrez Gene | 92610 |
Alt Symbol | T2BP, T6BP, TIFAA |
Species | Human |
Gene Type | protein-coding |
Description | TRAF-interacting protein with forkhead-associated domain |
Other Description | TRAF-interacting protein with FHA domain-containing protein A|TRAF-interacting protein with a forkhead-associated domain|TRAF2 binding protein|TRAF2-binding protein|TRAF6 binding protein|putative MAPK-activating protein PM14|putative NF-kappa-B-activating protein 20 |
Swissprots | Q96CG3 |
Accessions | AAY40963 EAX06273 Q96CG3 AB062110 BAB86902 AB097011 BAC77364 AB097038 BAC77391 AK292900 BAF85589 BC008294 AAH08294 BC014259 AAH14259 BM680110 BM718895 CA772080 DQ893681 ABM84607 DQ896122 ABM87121 XM_011532413 XP_011530715 NM_052864 NP_443096 |
Function | Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. {ECO:0000269|PubMed:12566447, ECO:0000269|PubMed:15492226}. |
Human TIFA full length protein - ab123199 from Abcam
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TAX1BP1 Antibody Blocking Peptide - LS-E3932 from LifeSpan Bioscience
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TIFA Antibody Blocking Peptide - LS-E10205 from LifeSpan Bioscience
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TIFA-Antibody-N-term-Blocking-Peptide - BP9587a from Abgent, a WuXi AppTec company
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TIFA protein (His tag) - 80R-2158 from Fitzgerald
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TIFA / T2BP (1-184, His-tag) - AR50239PU-N from Acris Antibodies
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TIFA / T2BP (1-184, His-tag) - AR50239PU-S from Acris Antibodies
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TIFA / T2BP - H00092610-P01-10 from Acris Antibodies
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TIFA / T2BP - H00092610-P01-25 from Acris Antibodies
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TIFA, 1-184aa, Human, His tag, E.coli - 01-P1414 from ARP American Research Products
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TIFA fusion protein - Ag1876 from Proteintech Group
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TIFA Human - PRPS-1048 from NeoScientific
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Recombinant Human TIFA protein - BP002217-PRO-1041 from Syd Labs
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TIFA, 1-184aa , Human, His tag, E.coli - GWB-P0624M from Genway Biotech
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Recombinant Human TIFA, GST-tagged - TIFA-3231H from Creative Biomart
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TIFA 1-184aa - CMB-1247 from Reagent Proteins
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Recombinant Human TRAF-interacting protein with FHA domain-containing protein A(TIFA) - CSB-YP839301HU CSB-EP839301HU CSB-BP839301HU CSB-MP839301HU from Cusabio
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TIFA, 1-184aa, Human, His tag, E.coli - ATGP1414 from ATGen
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TIFA - PAT-81454-1 from Nordic BioSite
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TIFA - PAT-81454-2 from Nordic BioSite
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