SPN

Gene Symbol SPN
Entrez Gene 6693
Alt Symbol CD43, GALGP, GPL115, LSN
Species Human
Gene Type protein-coding
Description sialophorin
Other Description galactoglycoprotein|leukocyte sialoglycoprotein|leukosialin|sialophorin (gpL115, leukosialin, CD43)
Swissprots P16150 A8K9B1
Accessions AAA51949 CAA36294 EAW80015 EAW80016 P16150 AK292626 BAF85315 AK313750 BAG36490 BC012350 AAH12350 BC035510 DA951208 DB108930 DQ892262 ABM83188 DQ895464 ABM86390 J04536 AAB59540 X60502 NM_001030288 NP_001025459 NM_003123 NP_003114
Function One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Top Pathways Cell adhesion molecules (CAMs), Epstein-Barr virus infection

CD43 (H-300) - sc-20819 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD43 (H-300): sc-20819. Western blot analysis of CD43 expression in Jurkat (A), K-562 (B) and Ramos (C) whole cell lysates.

CD43 (C-20) - sc-7052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD43 (C-20): sc-7052. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane staining.

CD43 (N-19) - sc-7053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD43 (N-19): sc-7053. Western blot analysis of CD43 expression in Ramos whole cell lysate.

CD43 (84-3C1) - sc-21774 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD43 (84-3C1): sc-21774. Western blot analysis of CD43 expression in Jurkat (A), K-562 (B), Ramos (C) and U-937 (D) whole cell lysates.

CD43 (DF-T1) - sc-6256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD43 (DF-T1): sc-6256. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization.

CD43 (MT1) - sc-51727 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
CD43 (MT1): sc-51727. Indirect FCM analysis of human peripheral blood leukocytes stained with CD43 (MT1), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

CD43 (2Q1350) - sc-70682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD43 (2Q1350): sc-70682. Western blot analysis of CD43 expression in Jurkat whole cell lysate.

CD43 (0.N.117) - sc-70681 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD43 (0.N.117): sc-70681. Western blot analysis of CD43 expression in Jurkat whole cell lysate.

Anti-CD43 antibody - ab68421 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-CD43 antibody (ab68421) at 1/500 dilution + immunising proteinSecondaryGoat Anti-Mouse IgG (H&L)-HRP at 2500

Anti-CD43 antibody - ab172141 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD43 antibody (ab172141) at 1 µg/mlLane 1 : CD43 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-CD43 antibody - ab76456 from Abcam

Prices $370.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
ab76456, at a 1/200 dilution, staining CD43 in formalin fixed, paraffin embedded human tonsil by Immunohistochemistry.

Anti-CD43 antibody [DF-T1] - ab76524 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone DF-T1

Anti-CD43 antibody [DF-T1] (Allophycocyanin) - ab46727 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DF-T1

Anti-CD43 antibody [DF-T1] (Biotin) - ab82471 from Abcam

Prices $216.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone DF-T1

Anti-CD43 antibody [DF-T1] (FITC) - ab82431 from Abcam

Prices $165.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DF-T1
Overlay histogram showing peripheral blood lymphocytes stained with ab82431 (red line). The cells incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab82431, 0.5 µg/1x106 cells) for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 FITC (2 µg/1x106 cells ) for 30 min at 22°C. Acquisition of >5,000 events was performed.

Anti-CD43 antibody [DF-T1] (Phycoerythrin) - ab82470 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone DF-T1

Anti-CD43 antibody [DF-T1], prediluted - ab964 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone DF-T1

Anti-CD43 antibody [MEM-59] - ab9088 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-59

Anti-CD43 antibody [MEM-59] (Biotin) - ab28104 from Abcam

Prices $216.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-59

Anti-CD43 antibody [MEM-59] (FITC) - ab21853 from Abcam

Prices $165.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-59
Overlay histogram showing peripheral blood lymphocytes stained with ab21853(red line). The cells incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab21853, 0.5 µg/1x106 cells) for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 FITC (2 µg/1x106 cells ) for 30 min at 22°C. Acquisition of >5,000 events was performed.

Anti-CD43 antibody [MEM-59] (Phycoerythrin) - ab60903 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-59

Anti-CD43 antibody [MEM-59], prediluted (Alexa Fluor® 488) - ab187599 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone MEM-59

Anti-CD43 antibody [MEM-59] - Low endotoxin, Azide free - ab46702 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MEM-59

Anti-CD43 antibody [MT-1] - ab74038 from Abcam

Prices $370.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone MT-1

Anti-CD43 antibody [MT1] - ab89691 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone MT1
ab89691 at 1/20 dilution staining CD43 in Human mantle cell lymphoma by Immunohistochemistry, Paraffin-embedded tissue. Note intense membrane staining of tumor cells
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