SPN

Gene Symbol	SPN
Entrez Gene	6693
Alt Symbol	CD43, GALGP, GPL115, LSN
Species	Human
Gene Type	protein-coding
Description	sialophorin
Other Description	galactoglycoprotein|leukocyte sialoglycoprotein|leukosialin|sialophorin (gpL115, leukosialin, CD43)
Swissprots	P16150 A8K9B1
Accessions	AAA51949 CAA36294 EAW80015 EAW80016 P16150 AK292626 BAF85315 AK313750 BAG36490 BC012350 AAH12350 BC035510 DA951208 DB108930 DQ892262 ABM83188 DQ895464 ABM86390 J04536 AAB59540 X60502 NM_001030288 NP_001025459 NM_003123 NP_003114
Function	One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Top Pathways	Cell adhesion molecules (CAMs), Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD43 full length protein - ab152704 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human CD43 protein fragment - ab171717 from Abcam Category Protein Prices $345.00 Sizes 100 µg Source E. coli Species Human

SPN / CD43 Antibody Blocking Peptide - LS-E3011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPN / CD43 Antibody Blocking Peptide - LS-E2957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SPN / CD43 Antibody Blocking Peptide - LS-E10228 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD43/Sialophorin Recombinant Protein - H00006693-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human CD43/Sialophorin Protein - H00006693-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

SPNCD43-Antibody-N-term-Blocking-peptide - BP14144a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPNCD43-Antibody-Center-Blocking-peptide - BP14085c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPN-Antibody-Center-Blocking-Peptide - BP9623c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E.coli SPN protein - orb246232 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Escherichia coli

Human ZG16 protein - orb81009 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

SPN protein (His tag) - 80R-3016 from Fitzgerald Category Protein Prices $355.00 Sizes 100 µg Source E.coli

CD43 / Leukosialin (20-253, His-tag) - AR51134PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

CD43 / Leukosialin (20-253, His-tag) - AR51134PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

CD43 / Leukosialin - H00006693-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD43 / Leukosialin - H00006693-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SPN, 20-253aa, Human, His tag, E.coli - 01-P2310 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

SPN fusion protein - Ag23595 from Proteintech Group Category Protein Species Human

SPN fusion protein - ag4836 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CD43 Human - GWB-C5E515 from Genway Biotech Category Protein Prices $75.00, $165.00, $6,190.00 Sizes 2 μg, 10 μg, 1000 μg Species Human

Recombinant Human SPN, His-tagged - SPN-2310H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Sialophorin - SPN-4264H from Creative Biomart Category Protein Source Human

Recombinant Human Leukosialin(SPN) - CSB-YP022590HU CSB-BP022590HU CSB-MP022590HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant huamn Leukosialin - CSB-EP022590HU from Cusabio Category Protein Source E.coli

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