SPN

Gene Symbol SPN
Entrez Gene 6693
Alt Symbol CD43, GALGP, GPL115, LSN
Species Human
Gene Type protein-coding
Description sialophorin
Other Description galactoglycoprotein|leukocyte sialoglycoprotein|leukosialin|sialophorin (gpL115, leukosialin, CD43)
Swissprots P16150 A8K9B1
Accessions AAA51949 CAA36294 EAW80015 EAW80016 P16150 AK292626 BAF85315 AK313750 BAG36490 BC012350 AAH12350 BC035510 DA951208 DB108930 DQ892262 ABM83188 DQ895464 ABM86390 J04536 AAB59540 X60502 NM_001030288 NP_001025459 NM_003123 NP_003114
Function One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
Top Pathways Cell adhesion molecules (CAMs), Epstein-Barr virus infection

CD43 CRISPR/Cas9 KO Plasmid (h) - sc-402688 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 HDR Plasmid (h) - sc-402688-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 Double Nickase Plasmid (h) - sc-402688-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 Double Nickase Plasmid (h2) - sc-402688-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 CRISPR Activation Plasmid (h) - sc-402688-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 CRISPR Activation Plasmid (h2) - sc-402688-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 Lentiviral Activation Particles (h) - sc-402688-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 Lentiviral Activation Particles (h2) - sc-402688-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 siRNA (h) - sc-29999 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD43 shRNA Plasmid (h) - sc-29999-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD43 shRNA (h) Lentiviral Particles - sc-29999-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD43/Sialophorin RNAi - H00006693-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CD43/Sialophorin RNAi - H00006693-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU150491 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20496 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20496 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPN siRNA (Human) - CRH4563 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPN - MBS8207344 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CD43 CRISPR/Cas9 KO Plasmid (h2) - sc-402688-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD43 HDR Plasmid (h2) - sc-402688-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPN shRNA Plasmid (Human) - CHH4563 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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