| Gene Symbol | SPN |
|---|---|
| Entrez Gene | 6693 |
| Alt Symbol | CD43, GALGP, GPL115, LSN |
| Species | Human |
| Gene Type | protein-coding |
| Description | sialophorin |
| Other Description | galactoglycoprotein|leukocyte sialoglycoprotein|leukosialin|sialophorin (gpL115, leukosialin, CD43) |
| Swissprots | P16150 A8K9B1 |
| Accessions | AAA51949 CAA36294 EAW80015 EAW80016 P16150 AK292626 BAF85315 AK313750 BAG36490 BC012350 AAH12350 BC035510 DA951208 DB108930 DQ892262 ABM83188 DQ895464 ABM86390 J04536 AAB59540 X60502 NM_001030288 NP_001025459 NM_003123 NP_003114 |
| Function | One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| Top Pathways | Cell adhesion molecules (CAMs), Epstein-Barr virus infection |