CDK8

Gene Symbol	CDK8
Entrez Gene	1024
Alt Symbol	K35
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 8
Other Description	CDK8 protein kinase|cell division protein kinase 8|mediator complex subunit CDK8|mediator of RNA polymerase II transcription subunit CDK8|protein kinase K35
Swissprots	Q6ISB5 Q5VUF3 P49336
Accessions	EAX08384 EAX08385 EAX08386 EAX08387 P49336 AK296084 BAG58839 AK296875 BAG59437 AY702976 AAU29339 BC069634 AAH69634 BC094784 BC104492 AAI04493 BC105950 AAI05951 BC107601 AAI07602 HG518164 CDI06887 L23208 L23311 X85753 CAA59754 XM_005266215 XP_005266272 XM_005266216 XP_005266273 XM_011534863 XP_011533165 XM_011534864 XP_011533166 XM_011534865 XP_011533167 NM_001260 NP_001251
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}.
Subcellular Location	Nucleus {ECO:0000305}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human CDK8 ELISA Kit (Cell-Based ELISA) - LS-F1881 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse CDK8 ELISA Kit (Sandwich ELISA) - LS-F8667 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.313-20 ng/ml

Human CDK8 ELISA Kit (Sandwich ELISA) - LS-F8666 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.127 ng/ml Range 0.313-20 ng/ml

Human CDK8 ELISA Kit - abx151017 from Abbexa Category ELISA Kit Sensitivity 0.127 ng/ml Range 0.313 ng/ml - 20 ng/ml

Cyclin Dependent Kinase 8, CDK8, Human, ELISA Kit - E-EL-H0316 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Cyclin Dependent Kinase 8 (CDK8), Human, ELISA Kit - SED243Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.127ng/mL Range 0.312-20ng/mL

Cyclin-dependent kinase 8 (CDK8), Human, ELISA Kit - E01C1563 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Cyclin Dependent Kinase 8, CDK8, Rabbit, ELISA Kit - E-EL-RB0678 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 8, CDK8, Chicken, ELISA Kit - E-EL-Ch1248 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin Dependent Kinase 8, CDK8, Porcine, ELISA Kit - E-EL-P1611 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin Dependent Kinase 8, CDK8, Monkey, ELISA Kit - E-EL-MK0197 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CDK8, ELISA Kit - MBS2510865 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CDK8, ELISA Kit - MBS2515048 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CDK8, ELISA Kit - MBS2512292 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

CDK8, ELISA Kit - MBS2506437 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

CDK8, ELISA Kit - MBS2500842 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CDK8 Colorimetric Cell-Based ELISA Kit - CB5133 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human CDK8(Cyclin Dependent Kinase 8) ELISA Kit - E-EL-H0316 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human CDK8 (Cyclin Dependent Kinase 8) CLIA Kit - E-CL-H0256 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

Cyclin dependent kinase 8 (CDK8), ELISA Kit - MBS7210532 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin Dependent Kinase 8 (CDK8), ELISA Kit - MBS2021300 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.127ng/mL. Range 0.313-20ng/mL

Cyclin Dependent Kinase 8 (CDK8), ELISA Kit - MBS2021071 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.053ng/mL. Range 0.156-10ng/mL

Cyclin-dependent kinase 8 (CDK8), ELISA Kit - MBS7217158 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase 8 (CDK8), ELISA Kit - MBS7238200 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cyclin-dependent kinase 8 (CDK8), ELISA Kit - MBS7207265 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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