| Gene Symbol |
CDK8
|
| Entrez Gene |
1024
|
| Alt Symbol |
K35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin-dependent kinase 8
|
| Other Description |
CDK8 protein kinase|cell division protein kinase 8|mediator complex subunit CDK8|mediator of RNA polymerase II transcription subunit CDK8|protein kinase K35
|
| Swissprots |
Q6ISB5 Q5VUF3 P49336
|
| Accessions |
EAX08384 EAX08385 EAX08386 EAX08387 P49336 AK296084 BAG58839 AK296875 BAG59437 AY702976 AAU29339 BC069634 AAH69634 BC094784 BC104492 AAI04493 BC105950 AAI05951 BC107601 AAI07602 HG518164 CDI06887 L23208 L23311 X85753 CAA59754 XM_005266215 XP_005266272 XM_005266216 XP_005266273 XM_011534863 XP_011533165 XM_011534864 XP_011533166 XM_011534865 XP_011533167 NM_001260 NP_001251
|
| Function |
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: Cdk8 Overexpression Lysate (Adult Normal) [NBL1-09046] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cdk8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2303_Cdk8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09046-img0002.jpg)