| Gene Symbol | CDK8 |
|---|---|
| Entrez Gene | 1024 |
| Alt Symbol | K35 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 8 |
| Other Description | CDK8 protein kinase|cell division protein kinase 8|mediator complex subunit CDK8|mediator of RNA polymerase II transcription subunit CDK8|protein kinase K35 |
| Swissprots | Q6ISB5 Q5VUF3 P49336 |
| Accessions | EAX08384 EAX08385 EAX08386 EAX08387 P49336 AK296084 BAG58839 AK296875 BAG59437 AY702976 AAU29339 BC069634 AAH69634 BC094784 BC104492 AAI04493 BC105950 AAI05951 BC107601 AAI07602 HG518164 CDI06887 L23208 L23311 X85753 CAA59754 XM_005266215 XP_005266272 XM_005266216 XP_005266273 XM_011534863 XP_011533165 XM_011534864 XP_011533166 XM_011534865 XP_011533167 NM_001260 NP_001251 |
| Function | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}. |
| Subcellular Location | Nucleus {ECO:0000305}. |