CDK8

Gene Symbol	CDK8
Entrez Gene	1024
Alt Symbol	K35
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 8
Other Description	CDK8 protein kinase|cell division protein kinase 8|mediator complex subunit CDK8|mediator of RNA polymerase II transcription subunit CDK8|protein kinase K35
Swissprots	Q6ISB5 Q5VUF3 P49336
Accessions	EAX08384 EAX08385 EAX08386 EAX08387 P49336 AK296084 BAG58839 AK296875 BAG59437 AY702976 AAU29339 BC069634 AAH69634 BC094784 BC104492 AAI04493 BC105950 AAI05951 BC107601 AAI07602 HG518164 CDI06887 L23208 L23311 X85753 CAA59754 XM_005266215 XP_005266272 XM_005266216 XP_005266273 XM_011534863 XP_011533165 XM_011534864 XP_011533166 XM_011534865 XP_011533167 NM_001260 NP_001251
Function	Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation. {ECO:0000269|PubMed:10993082, ECO:0000269|PubMed:15546612}.
Subcellular Location	Nucleus {ECO:0000305}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cdk8 protein fragment - ab158089 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CDK8 Antibody Blocking Peptide - LS-E1339 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK8 Antibody Blocking Peptide - LS-E4038 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK8 Antibody Blocking Peptide - LS-E10500 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK8 Antibody Blocking Peptide - LS-E10587 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CDK8 Antibody Blocking Peptide - LS-E9024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human CDK8 Protein - H00001024-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CDK8 Peptide - P2529 from Novus Biologicals Category Peptide Species Human

CDK8-Antibody-Center-Blocking-peptide - BP11972c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK8-Antibody-N-term-Blocking-Peptide - BP7524a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK8 Blocking Peptide - 33R-3399 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CDK8 Blocking Peptide - abx062065 from Abbexa Category Peptide Species Human, Mouse, Rat, Zebrafish

CDK8 - H00001024-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CDK8 - H00001024-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CDK8 - P4663 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

CDK8 - P5517 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

CDK8 fusion protein - ag15606 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CDK8 fusion protein - Ag17148 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CDK-8 Human - PKPS-317 from NeoScientific Category Protein Prices $65.00, $169.00, $6,240.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Cyclin-Dependent Kinase 8 Enzyme - BP002452-PKA-310 from Syd Labs Category Protein Prices $160.00, $4,800.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human CDK8/CCNC, GST&His-tagged - CDK8/CCNC-256H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells Species Human

Recombinant Human CDK8, His-tagged - CDK8-08H from Creative Biomart Category Protein Source Escherichia Coli.

Recombinant Human CDK8, His-tagged - CDK8-09H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CDK8, MYC/DDK-tagged - CDK8-10H from Creative Biomart Category Protein Source HEK293 cells Species Human

Recombinant Human CDK8, GST-tagged - CDK8-11H from Creative Biomart Category Protein Source Wheat germ Species Human

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