Gene Symbol | RAET1G |
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Entrez Gene | 353091 |
Alt Symbol | ULBP5 |
Species | Human |
Gene Type | protein-coding |
Description | retinoic acid early transcript 1G |
Other Description | UL-16 binding protein 5|retinoic acid early transcript 1G protein |
Swissprots | Q6H3X2 Q6H3X3 |
Accessions | AFP99104 AFP99105 AFP99106 EAW47779 Q6H3X3 AK310157 AY172579 AAO22238 AY172580 AAO22239 BC096719 AAH96719 BC098152 AAH98152 HY165961 XM_011535800 XP_011534102 NM_001001788 NP_001001788 NR_130110 |
Function | Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor. {ECO:0000269|PubMed:15240696}. |
Subcellular Location | Isoform 1: Cell membrane {ECO:0000269|PubMed:19223974}; Single-pass type I membrane protein {ECO:0000269|PubMed:19223974}. Cell membrane {ECO:0000269|PubMed:19223974}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19223974}. Endoplasmic reticulum {ECO:0000269|PubMed:19223974}. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface. |
Tissue Specificity | Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974}. |
Top Pathways | Natural killer cell mediated cytotoxicity |
RAET1G (S-17) - sc-324939 from Santa Cruz Biotechnology
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RAET1G (C-16) - sc-324941 from Santa Cruz Biotechnology
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ULBP5 (6D10) - sc-53134 from Santa Cruz Biotechnology
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Anti-RAET1G antibody - ab169358 from Abcam
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Anti-ULBP5 / RAET1G Antibody (aa162-211) - LS-C152017 from LifeSpan Bioscience
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ULBP-5/RAET1G Antibody - H00353091-B01 from Novus Biologicals
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ULBP-5/RAET1G Antibody - H00353091-B01P from Novus Biologicals
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Anti-RAET1G antibody produced in mouse - SAB1411732 from Sigma-Aldrich
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RAET1G Antibody - middle region (ARP65597_P050) - ARP65597_P050 from Aviva Systems Biology
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RAET1G antibody - H00353091-B01 from Acris Antibodies
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RAET1G antibody - H00353091-B01P from Acris Antibodies
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Anti-RAET1G (full length) polyclonal antibody - DPABH-07979 from Creative Diagnostics
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Anti-RAET1G (aa 162-211) polyclonal antibody - DPABH-25515 from Creative Diagnostics
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Anti-RAET1G monoclonal antibody - DCABH-201334 from Creative Diagnostics
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RAET1G antibody - TA338350 from Acris Antibodies
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Anti-RAET1G Antibody A11123 - A11123 from Boster Bio
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RAET1G Antibody - middle region : Biotin (ARP65597_P050-Biotin) - ARP65597_P050-Biotin from Aviva Systems Biology
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RAET1G Antibody - middle region : FITC (ARP65597_P050-FITC) - ARP65597_P050-FITC from Aviva Systems Biology
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RAET1G Antibody - middle region : HRP (ARP65597_P050-HRP) - ARP65597_P050-HRP from Aviva Systems Biology
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Anti-ULBP5 / RAET1G Antibody (aa162-211, FITC) - LS-C473253 from LifeSpan Bioscience
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Anti-ULBP5 / RAET1G Antibody (aa162-211, HRP) - LS-C473254 from LifeSpan Bioscience
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Anti-ULBP5 / RAET1G Antibody (aa162-211, Biotin) - LS-C473252 from LifeSpan Bioscience
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