Gene Symbol | RAET1G |
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Entrez Gene | 353091 |
Alt Symbol | ULBP5 |
Species | Human |
Gene Type | protein-coding |
Description | retinoic acid early transcript 1G |
Other Description | UL-16 binding protein 5|retinoic acid early transcript 1G protein |
Swissprots | Q6H3X2 Q6H3X3 |
Accessions | AFP99104 AFP99105 AFP99106 EAW47779 Q6H3X3 AK310157 AY172579 AAO22238 AY172580 AAO22239 BC096719 AAH96719 BC098152 AAH98152 HY165961 XM_011535800 XP_011534102 NM_001001788 NP_001001788 NR_130110 |
Function | Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor. {ECO:0000269|PubMed:15240696}. |
Subcellular Location | Isoform 1: Cell membrane {ECO:0000269|PubMed:19223974}; Single-pass type I membrane protein {ECO:0000269|PubMed:19223974}. Cell membrane {ECO:0000269|PubMed:19223974}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19223974}. Endoplasmic reticulum {ECO:0000269|PubMed:19223974}. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface. |
Tissue Specificity | Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974}. |
Top Pathways | Natural killer cell mediated cytotoxicity |
RAET1G CRISPR/Cas9 KO Plasmid (h) - sc-410520 from Santa Cruz Biotechnology
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RAET1G HDR Plasmid (h) - sc-410520-HDR from Santa Cruz Biotechnology
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RAET1G Double Nickase Plasmid (h) - sc-410520-NIC from Santa Cruz Biotechnology
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RAET1G Double Nickase Plasmid (h2) - sc-410520-NIC-2 from Santa Cruz Biotechnology
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RAET1G CRISPR Activation Plasmid (h) - sc-410520-ACT from Santa Cruz Biotechnology
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RAET1G CRISPR Activation Plasmid (h2) - sc-410520-ACT-2 from Santa Cruz Biotechnology
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RAET1G Lentiviral Activation Particles (h) - sc-410520-LAC from Santa Cruz Biotechnology
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RAET1G Lentiviral Activation Particles (h2) - sc-410520-LAC-2 from Santa Cruz Biotechnology
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RAET1G siRNA (h) - sc-106477 from Santa Cruz Biotechnology
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RAET1G shRNA Plasmid (h) - sc-106477-SH from Santa Cruz Biotechnology
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RAET1G shRNA (h) Lentiviral Particles - sc-106477-V from Santa Cruz Biotechnology
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ULBP-5/RAET1G RNAi - H00353091-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17912 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17912 from Sigma-Aldrich
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RAET1G siRNA (Human) - CRJ7559 from Cohesion Biosciences
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RAET1G - MBS8213896 from MyBioSource
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shRNA set against Human RAET1G (NM_001001788.2) - SHH389188 from Creative biogene
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RAET1G shRNA Plasmid (Human) - CHJ7559 from Cohesion Biosciences
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RAET1G miRNA 3'UTR clone - MiUTR1H-08603 from Creative biogene
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