| Gene Symbol |
RAET1G
|
| Entrez Gene |
353091
|
| Alt Symbol |
ULBP5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoic acid early transcript 1G
|
| Other Description |
UL-16 binding protein 5|retinoic acid early transcript 1G protein
|
| Swissprots |
Q6H3X2 Q6H3X3
|
| Accessions |
AFP99104 AFP99105 AFP99106 EAW47779 Q6H3X3 AK310157 AY172579 AAO22238 AY172580 AAO22239 BC096719 AAH96719 BC098152 AAH98152 HY165961 XM_011535800 XP_011534102 NM_001001788 NP_001001788 NR_130110
|
| Function |
Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor. {ECO:0000269|PubMed:15240696}.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000269|PubMed:19223974}; Single-pass type I membrane protein {ECO:0000269|PubMed:19223974}. Cell membrane {ECO:0000269|PubMed:19223974}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19223974}. Endoplasmic reticulum {ECO:0000269|PubMed:19223974}. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.
|
| Tissue Specificity |
Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. {ECO:0000269|PubMed:15240696, ECO:0000269|PubMed:19223974}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|