GP6

Gene Symbol	GP6
Entrez Gene	51206
Alt Symbol	BDPLT11, GPIV, GPVI
Species	Human
Gene Type	protein-coding
Description	glycoprotein VI (platelet)
Other Description	glycoprotein 6\|platelet collagen receptor\|platelet glycoprotein VI
Swissprots	Q9UIF2 Q9HCN6 Q9HCN7
Accessions	AAN86273 BAB12248 EAW72324 EAW72325 EAW72326 Q9HCN6 AB035073 BAA89353 AB043819 BAB12245 AB043820 BAB12246 AB043821 BAB12247 BC069485 BC104832 AAI04833 BC111963 AAI11964 BQ216894 NM_001083899 NP_001077368 NM_001256017 NP_001242946 NM_016363 NP_057447
Function	Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. {ECO:0000269\|PubMed:10961879}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Megakaryocytes and platelets. {ECO:0000269\|PubMed:10961879}.
Top Pathways	ECM-receptor interaction

GPVI (H-5) - sc-390410 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

GPVI (H-5): sc-390410. Western blot analysis of GPVI expression in MEG-01 whole cell lysate.

GPVI (H-139) - sc-20149 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

GPVI (H-139): sc-20149. Western blot analysis of GPVI expression in MEG-01 (A), SK-N-SH (B), SJRH30 (C), IMR-32 (D) and SH-SY5Y (E) whole cell lysates.

GPVI (N-20) - sc-23551 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-Glycoprotein VI antibody - ab82807 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Glycoprotein VI antibody (ab82807) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-Glycoprotein VI antibody - ab63925 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Glycoprotein VI antibody (ab63925) at 4 µg/mlLane 1 : Jurkat cell lysateLane 2 : Induced Jurkat cell lysateObserved band size : 58 kDa (why is the actual band size different from the predicted?)

Anti-Glycoprotein VI antibody [EPR8347] - ab129019 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8347

Anti-Glycoprotein VI antibody [EPR8347] (ab129019) at 1/10000 dilution + Human platelet lysate at 10 µgSecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution

Anti-Glycoprotein VI antibody - C-terminal - ab175276 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Flow cytometric analysis of K562 cells (right histogram) labeling Glycoprotein VI with ab175276 at 1/10 dilution compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis

Anti-GP6 / GPVI Antibody (C-Terminus) - LS-C123623 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody - LS-C146963 from LifeSpan Bioscience

Prices	$410.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus, APC) - LS-C235862 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus, AP) - LS-C235863 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (aa216-265) - LS-C81014 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-GP6 / GPVI Antibody (C-Terminus, Biotin) - LS-C235864 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus, FITC) - LS-C235865 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus, PE) - LS-C235868 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus, Azide-free, HRP) - LS-C249106 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (Internal) - LS-C83911 from LifeSpan Bioscience

Prices	$325.00, $890.00
Sizes	100 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of GPVI in mouse brain lysate with GPVI antibody at 1 ug/ml in either the absence or (B) the presence of blocking peptide.

Anti-GP6 / GPVI Antibody (aa86-231, Biotin) - LS-C298093 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (aa86-231, FITC) - LS-C302584 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (aa63-252) - LS-C311919 from LifeSpan Bioscience

Prices	$250.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (C-Terminus) - LS-C321713 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (Internal, clone EPR8347) - LS-C154462 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8347

Western blot analysis on human platelet lysate using anti-GP6 / GPVI antibody.

Anti-GP6 / GPVI Antibody (aa86-231) - LS-C294302 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GP6 / GPVI Antibody (aa316-345) - LS-C166591 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

GP6 Antibody western blot of K562 cell line lysates (15 ug/lane). The GP6 antibody detected the GP6 protein (arrow).

Anti-GP6 / GPVI Antibody (C-Terminus) - LS-C83910 from LifeSpan Bioscience

Prices	$345.00, $1,035.00
Sizes	100 µg, 500 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of GPVI in human heart tissue with GPVI antibody at 10 ug/ml.

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