GP6

Gene Symbol	GP6
Entrez Gene	51206
Alt Symbol	BDPLT11, GPIV, GPVI
Species	Human
Gene Type	protein-coding
Description	glycoprotein VI (platelet)
Other Description	glycoprotein 6|platelet collagen receptor|platelet glycoprotein VI
Swissprots	Q9UIF2 Q9HCN6 Q9HCN7
Accessions	AAN86273 BAB12248 EAW72324 EAW72325 EAW72326 Q9HCN6 AB035073 BAA89353 AB043819 BAB12245 AB043820 BAB12246 AB043821 BAB12247 BC069485 BC104832 AAI04833 BC111963 AAI11964 BQ216894 NM_001083899 NP_001077368 NM_001256017 NP_001242946 NM_016363 NP_057447
Function	Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. {ECO:0000269|PubMed:10961879}.
Subcellular Location	Isoform 1: Cell membrane; Single-pass membrane protein.
Tissue Specificity	Megakaryocytes and platelets. {ECO:0000269|PubMed:10961879}.
Top Pathways	ECM-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPVI CRISPR/Cas9 KO Plasmid (h) - sc-404055 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI HDR Plasmid (h) - sc-404055-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI Double Nickase Plasmid (h) - sc-404055-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI Double Nickase Plasmid (h2) - sc-404055-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI CRISPR Activation Plasmid (h) - sc-404055-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI CRISPR Activation Plasmid (h2) - sc-404055-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI Lentiviral Activation Particles (h) - sc-404055-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI Lentiviral Activation Particles (h2) - sc-404055-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GPVI siRNA (h) - sc-43813 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GPVI shRNA Plasmid (h) - sc-43813-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GPVI shRNA (h) Lentiviral Particles - sc-43813-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GPVI RNAi - H00051206-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU076911 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9498 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9498 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08661 from Sigma-Aldrich Category miRNA

GP6 siRNA (Human) - CRH9607 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GP6 - MBS8208608 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human GP6 (NM_016363.4) - SHH305570 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human GP6(NM_001083899.1) - SHH095213 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human GP6(NM_016363.4) - SHH095249 from Creative biogene Category siRNA Species Reactivities Human

Human GP6 siRNA - orb270109 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GP6 shRNA Plasmid (Human) - CHH9607 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

GP6 miRNA 3'UTR clone - MiUTR1H-04153 from Creative biogene Species Reactivities Human

GP6 miRNA 3'UTR clone - MiUTR1H-04154 from Creative biogene Species Reactivities Human

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