| Gene Symbol |
GP6
|
| Entrez Gene |
51206
|
| Alt Symbol |
BDPLT11, GPIV, GPVI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycoprotein VI (platelet)
|
| Other Description |
glycoprotein 6|platelet collagen receptor|platelet glycoprotein VI
|
| Swissprots |
Q9UIF2 Q9HCN6 Q9HCN7
|
| Accessions |
AAN86273 BAB12248 EAW72324 EAW72325 EAW72326 Q9HCN6 AB035073 BAA89353 AB043819 BAB12245 AB043820 BAB12246 AB043821 BAB12247 BC069485 BC104832 AAI04833 BC111963 AAI11964 BQ216894 NM_001083899 NP_001077368 NM_001256017 NP_001242946 NM_016363 NP_057447
|
| Function |
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. {ECO:0000269|PubMed:10961879}.
|
| Subcellular Location |
Isoform 1: Cell membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Megakaryocytes and platelets. {ECO:0000269|PubMed:10961879}.
|
| Top Pathways |
ECM-receptor interaction
|