| Gene Symbol |
CERK
|
| Entrez Gene |
64781
|
| Alt Symbol |
LK4, dA59H18.2, dA59H18.3, hCERK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ceramide kinase
|
| Other Description |
acylsphingosine kinase|lipid kinase 4|lipid kinase LK4
|
| Swissprots |
Q9UGE5 Q8TCT0 Q6NX59 A8K611 Q9BYB3 A0JNT4
|
| Accessions |
EAW73438 EAW73439 EAW73440 EAW73441 EAW73442 Q8TCT0 AB051433 BAB33316 AB079066 BAC01154 AJ457828 CAD29884 AK025083 AK026892 BAB15585 AK291476 BAF84165 AL137600 AL832794 BC004278 AAH04278 BC008382 BC067255 AAH67255 BC108712 AAI08713 BC126940 AAI26941 BQ710170 BU187541 CR456404 CAG30290 CR457365 CAG33646 CU012949 CAK54380 CU013237 CAK54679 XM_011530315 XP_011528617 NM_182661 NM_022766 NP_073603
|
| Function |
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19168031}. Membrane {ECO:0000269|PubMed:19168031}; Peripheral membrane protein {ECO:0000269|PubMed:19168031}.
|
| Tissue Specificity |
High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
|
| Top Pathways |
Sphingolipid metabolism
|
![Western Blot: Ceramide Kinase Lysate [NBL1-09110] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for CERK](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7827_Ceramide%2520Kinase%2520Lysate-Western%2520Blot-NBL1-09110-img0001.jpg)