CYP4F2

Gene Symbol CYP4F2
Entrez Gene 8529
Alt Symbol CPF2
Species Human
Gene Type protein-coding
Description cytochrome P450, family 4, subfamily F, polypeptide 2
Other Description 20-HETE synthase|20-hydroxyeicosatetraenoic acid synthase|CYPIVF2|arachidonic acid omega-hydroxylase|cytochrome P450 4F2|cytochrome P450, subfamily IVF, polypeptide 2|cytochrome P450-LTB-omega|leukotriene-B(4) 20-monooxygenase 1|leukotriene-B(4) omega-hydroxylase 1|phylloquinone omega-hydroxylase CYP4F2
Swissprots A0A024R7K3 Q9UIU8 Q9NNZ0 Q6NWT6 A8K425 P78329 Q16677 B4DV75 Q6NWT4
Accessions AAC27730 AAF86378 AAL67578 BAA75823 EAW84508 EAW84509 EAW84510 P78329 AK290790 BAF83479 AK296200 BAG58928 AK300961 BAG62587 AK313705 BC067437 AAH67437 BC067438 BC067439 AAH67439 BC067440 AAH67440 D26480 BAA05490 DC362034 U02388 AAC50052 NM_001082 NP_001073
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:2413
Subcellular Location Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
Tissue Specificity Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572). {ECO:0000269|PubMed:10492403, ECO:0000269|PubMed:10660572}.
Top Pathways Arachidonic acid metabolism

CYP4F2 (H-40) - sc-67156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CYP4F2 (H-40): sc-67156. Western blot analysis of CYP4F11 expression in non-transfected 293T: sc-117752 (A), human CYP4F11 transfected 293T: sc-158420 (B) and Hep G2 (C) whole cell lysates.

CYP4F2 (N-19) - sc-46888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CYP4F2 antibody - ab111741 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111741 at 1/50 dilution staining CYP4F2 in paraffin-embedded Human Liver carcinoma tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.

Anti-CYP4F2 antibody - ab125399 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CYP4F2 antibody (ab125399) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-CYP4F2 Antibody (Met66) - LS-C193135 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4F2 Antibody (aa76-121) - LS-C313734 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CYP4F2 Antibody (aa41-90) - LS-C119509 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human liver carcinoma, using Cytochrome P450 4F2 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CYP4F2 Antibody (aa288-337) - LS-C146501 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CYP4F2 antibody LS-C146501 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

CYP4F2 Antibody - NBP1-86461 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP4F2 Antibody [NBP1-86461] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

CYP4F2 Antibody - NBP2-16070 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CYP4F2 Antibody [NBP2-16070] - Sample (20 ug ) A: Hela whole cell lysate B: Hela cell membrane 7. 5% SDS PAGE gel, diluted at 1:1000.

Anti-CYP4F2 antibody produced in rabbit - HPA014048 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CYP4F2: <B>Cat. No. HPA014048</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver shows moderate cytoplasmic positivity in hepatocytes.

Anti-CYP4F2 antibody produced in rabbit - SAB2700259 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CYP4F2: <B>Cat. No. SAB2700259</B>: Western Blot analysis of CYP4F2 in extracts from <B>Lanes</B><BR/>A. HeLa whole cell lysate <BR/>B. HeLa cell membrane fraction using <B>Cat. No. SAB2700259</B> at a 1:1000 dilution.

CYP4F2 antibody - C-terminal region (ARP63725_P050) - ARP63725_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Cytochrome P450 4F2 antibody [N2C2], Internal - GTX102722 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-Cytochrome P450 4F2 antibody [N2C2], Internal used in Western blot. GTX102722

CYP4F2 Antibody (OAAF02964) - OAAF02964 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

CYP4F2 antibody - orb182851 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal

Cytochrome P450 4F2 antibody - 70R-32424 from Fitzgerald

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Cytochrome P450 4F2 Antibody - abx008516 from Abbexa

Host Rabbit
Clonality Polyclonal

Anti-CYP4F2 (M66) - 31-B9135 from ARP American Research Products

Prices $169.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

CYP4F2-Specific antibody - 20010-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

Anti-CYP4F2 antibody - STJ92600 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

Cytochrome P450 4F2 Polyclonal Antibody - PA001401-C12283 from Syd Labs

Prices $150.00, $250.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal

Cytochrome P450 4F2 Antibody - 34244 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using Cytochrome P450 4F2 antibody #34244.
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