| Gene Symbol |
SMYD2
|
| Entrez Gene |
56950
|
| Alt Symbol |
HSKM-B, KMT3C, ZMYND14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SET and MYND domain containing 2
|
| Other Description |
N-lysine methyltransferase SMYD2|SET and MYND domain-containing protein 2|histone methyltransferase SMYD2|lysine N-methyltransferase 3C|zinc finger, MYND domain containing 14
|
| Swissprots |
I6L9H7 Q9NRG4 Q96AI4 Q5VSH9 Q4V765 B2R9P9
|
| Accessions |
EAW93355 EAW93356 EAW93357 EAW93358 Q9NRG4 AF070592 AF226053 AAF86953 AK091590 AK098683 AK313868 BAG36596 AW474469 BC017080 AAH17080 BC028104 AAH28104 BC039890 BC049367 AAH49367 BC057793 BC068511 BC094747 BC098133 AAH98133 BC098276 AAH98276 BC098305 AAH98305 BC098335 AAH98335 BG723585 XR_426790 NM_020197 NP_064582
|
| Function |
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
|
![Western Blot: SMYD2 Overexpression Lysate (Adult Normal) [NBL1-16261] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMYD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7477_SMYD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16261-img0002.jpg)