SMYD2

Gene Symbol	SMYD2
Entrez Gene	56950
Alt Symbol	HSKM-B, KMT3C, ZMYND14
Species	Human
Gene Type	protein-coding
Description	SET and MYND domain containing 2
Other Description	N-lysine methyltransferase SMYD2|SET and MYND domain-containing protein 2|histone methyltransferase SMYD2|lysine N-methyltransferase 3C|zinc finger, MYND domain containing 14
Swissprots	I6L9H7 Q9NRG4 Q96AI4 Q5VSH9 Q4V765 B2R9P9
Accessions	EAW93355 EAW93356 EAW93357 EAW93358 Q9NRG4 AF070592 AF226053 AAF86953 AK091590 AK098683 AK313868 BAG36596 AW474469 BC017080 AAH17080 BC028104 AAH28104 BC039890 BC049367 AAH49367 BC057793 BC068511 BC094747 BC098133 AAH98133 BC098276 AAH98276 BC098305 AAH98305 BC098335 AAH98335 BG723585 XR_426790 NM_020197 NP_064582
Function	Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMYD2 - MBS1272003 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC098305

Human SMYD2 ORF Clone(NM_020197.2) - CDCL176461 from Creative Biomart Species Human Accession NM_020197.2

Human SMYD2 ORF Clone(NM_020197.2) - CDCL176462 from Creative Biomart Species Human Accession NM_020197.2

human SMYD2 ORF clone - CDCH083818 from Creative Biomart Species Human Accession NM_020197

human SMYD2 ORF clone - CDCH083819 from Creative Biomart Species Human Accession NM_020197

human SMYD2 ORF clone - CDCH083820 from Creative Biomart Species Human Accession NM_020197

human SMYD2 ORF clone - CDCH083821 from Creative Biomart Species Human Accession NM_020197

Human SMYD2 Gene ORF cDNA clone in cloning vector - HG11093-M from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid - HG11093-UT from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11093-NY from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11093-ACG from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-His tag - HG11093-NH from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11093-M-F from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid - HG11093-M-N from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-His tag - HG11093-CH from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11093-NF from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11093-NM from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11093-CF from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11093-ANG from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11093-CM from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11093-ACR from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11093-ANR from Sino Biological Species Human

Human SMYD2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11093-CY from Sino Biological Species Human

human SMYD2 ORF clone (NM_020197.2) - CDCH083820 from Creative biogene Species Human

Human SMYD2 ORF Clone (BC098305) - CDCS415022 from Creative biogene Species Human Accession Q9NRG4

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