SMYD2

Gene Symbol	SMYD2
Entrez Gene	56950
Alt Symbol	HSKM-B, KMT3C, ZMYND14
Species	Human
Gene Type	protein-coding
Description	SET and MYND domain containing 2
Other Description	N-lysine methyltransferase SMYD2|SET and MYND domain-containing protein 2|histone methyltransferase SMYD2|lysine N-methyltransferase 3C|zinc finger, MYND domain containing 14
Swissprots	I6L9H7 Q9NRG4 Q96AI4 Q5VSH9 Q4V765 B2R9P9
Accessions	EAW93355 EAW93356 EAW93357 EAW93358 Q9NRG4 AF070592 AF226053 AAF86953 AK091590 AK098683 AK313868 BAG36596 AW474469 BC017080 AAH17080 BC028104 AAH28104 BC039890 BC049367 AAH49367 BC057793 BC068511 BC094747 BC098133 AAH98133 BC098276 AAH98276 BC098305 AAH98305 BC098335 AAH98335 BG723585 XR_426790 NM_020197 NP_064582
Function	Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971, ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756, ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458, ECO:0000269|PubMed:21880715}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KMT3C / SMYD2 full length protein - ab107699 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human KMT3C / SMYD2 full length protein - ab153431 from Abcam Category Protein Source Wheat germ Species Human

Human KMT3C / SMYD2 full length protein - ab196427 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

SMYD2 Antibody Blocking Peptide - LS-E218 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMYD2 Antibody Blocking Peptide - LS-E18282 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMYD2 Antibody Blocking Peptide - LS-E17570 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMYD2 Recombinant Protein - H00056950-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SMYD2 Peptide - P0173 from Novus Biologicals Category Peptide Species Human

SMYD2-Antibody-N-term-Blocking-Peptide - BP1044a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human HSKM B protein - orb83424 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Insect Species Human

SMYD2 Blocking Peptide - 33R-8053 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMYD2 Blocking Peptide - 33R-8646 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMYD2 - H00056950-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMYD2 - H00056950-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMYD2 fusion protein - Ag17190 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SMYD2 fusion protein - ag15823 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant SMYD2 protein - 31323 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant SMYD2 Y240F protein - 31324 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human SET And MYND Domain Containing 2, GST-tagged - SMYD2-1633H from Creative Biomart Category Protein Species Human

Recombinant Human SET And MYND Domain Containing 2 - SMYD2-469H from Creative Biomart Category Protein Source Sf9 .

Recombinant Human SMYD2 - SMYD2-27745TH from Creative Biomart Category Protein Source Baculovirus infected sf9 cells

Recombinant Human SMYD2, GST-tagged - SMYD2-6967H from Creative Biomart Category Protein Source Sf9 Cells Species Human

Recombinant Human SMYD2, His-tagged - SMYD2-2828H from Creative Biomart Category Protein Source E.coli Species Human

Human SMYD2 / KMT3C Protein (His Tag) - 11093-H07B-20 from Sino Biological Category Protein Prices $158.00, $158.00 Sizes 20 µg, 50 µg Source Baculovirus-Insect Cells Species Human

SMYD2 protein-GST fusion - 009-001-T43 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

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