Gene Symbol | SIRPG |
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Entrez Gene | 55423 |
Alt Symbol | CD172g, SIRP-B2, SIRPB2, SIRPgamma, bA77C3.1 |
Species | Human |
Gene Type | protein-coding |
Description | signal-regulatory protein gamma |
Other Description | CD172 antigen-like family member B|CD172g antigen|SIRP beta 2|SIRP-beta-2|SIRP-gamma|signal-regulatory protein beta 2|signal-regulatory protein beta-2 |
Swissprots | Q9NQK8 Q5D051 Q5JV25 B1AKP6 Q9P1W8 Q8WWA5 Q5MKL4 |
Accessions | EAX10615 EAX10616 EAX10617 EAX10618 Q9P1W8 AA446468 AB042624 BAA95692 AK124224 AK292745 BAF85434 AY748247 AAV88530 AY748248 AAV88531 BC020629 AAH20629 BC064532 AAH64532 DA008008 DB046293 HQ448099 ADQ32580 XM_005260749 XP_005260806 XM_011529286 XP_011527588 XM_011529287 XP_011527589 NM_001039508 NP_001034597 NM_018556 NP_061026 NM_080816 NP_543006 |
Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269|PubMed:15383453}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}. |
Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. {ECO:0000269|PubMed:11185750, ECO:0000269|PubMed:15383453}. |
Top Pathways | Osteoclast differentiation |
SIRP-γ (OX116) - sc-53111 from Santa Cruz Biotechnology
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SIRP-γ (OX117) - sc-53112 from Santa Cruz Biotechnology
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SIRP-γ (LSB2.20) - sc-53604 from Santa Cruz Biotechnology
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SIRP-γ (OX118) - sc-53113 from Santa Cruz Biotechnology
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SIRP-γ (OX119) - sc-53114 from Santa Cruz Biotechnology
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SIRP-γ (D-14) - sc-68818 from Santa Cruz Biotechnology
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SIRP-γ (S-12) - sc-68820 from Santa Cruz Biotechnology
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Anti-CD172 gamma antibody - ab96064 from Abcam
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Anti-CD172 gamma antibody - ab129657 from Abcam
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Anti-CD172 gamma antibody - ab118750 from Abcam
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Anti-CD172 gamma antibody - ab172783 from Abcam
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Anti-CD172 gamma antibody [OX119] (Phycoerythrin) - ab66229 from Abcam
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Anti-SIRPG Antibody (clone OX119, FITC) - LS-C58160 from LifeSpan Bioscience
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Anti-SIRPG Antibody (clone OX119) - LS-C58159 from LifeSpan Bioscience
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Anti-SIRPG Antibody (clone OX119, RPE) - LS-C58162 from LifeSpan Bioscience
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Anti-SIRPG Antibody (FITC) - LS-C132120 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, AP) - LS-C240803 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, FITC) - LS-C240805 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, APC) - LS-C240804 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, Biotin) - LS-C240806 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, PE) - LS-C240808 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa193-221, Azide-free, HRP) - LS-C248162 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa192-221) - LS-C325124 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa84-133) - LS-C200669 from LifeSpan Bioscience
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Anti-SIRPG Antibody (aa100-148) - LS-C186775 from LifeSpan Bioscience
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